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    nkb-1 Sodium/potassium-transporting ATPase subunit beta-1 [ Caenorhabditis elegans ]

    Gene ID: 182726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nkb-1
    Official Full Name
    Sodium/potassium-transporting ATPase subunit beta-1
    Primary source
    WormBase:WBGene00007646
    Locus tag
    CELE_C17E4.9
    See related
    AllianceGenome:WB:WBGene00007646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase activator activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of sodium:potassium-exchanging ATPase complex. Is expressed in intestine; neurons; and non-striated muscle. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; essential hypertension; and stomach cancer. Orthologous to several human genes including ATP1B4 (ATPase Na+/K+ transporting family member beta 4); ATP1B1 (ATPase Na+/K+ transporting subunit beta 1); and ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nkb-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (9431249..9433828)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting-associated protein 72 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PRKC apoptosis WT1 regulator protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Na+/K+ ATPase regulates the expression and localization of acetylcholine receptors in a pump activity-independent manner. Doi M, et al. Mol Cell Neurosci, 2008 Aug. PMID 18599311, Free PMC Article
    2. Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans. Takeuchi T, et al. J Biochem, 2013 Nov. PMID 23935187
    3. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Simmer F, et al. Curr Biol, 2002 Aug 6. PMID 12176360
    4. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    5. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of sodium:potassium-exchanging ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sodium:potassium-exchanging ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sodium/potassium-transporting ATPase subunit beta-1
    NP_492506.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9431249..9433828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060105.8 → NP_492506.1  Sodium/potassium-transporting ATPase subunit beta-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492506.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93235
      Conserved Domains (1) summary
      pfam00287
      Location:27 → 303
      Na_K-ATPase; Sodium / potassium ATPase beta chain

    RNA

    1. NR_136361.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93235.1

    Gene LinkOut

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