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    wrt-4 Warthog protein 4 N-product [ Caenorhabditis elegans ]

    Gene ID: 181664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wrt-4
    Official Full Name
    Warthog protein 4 N-product
    Primary source
    WormBase:WBGene00006950
    Locus tag
    CELE_ZK678.5
    See related
    AllianceGenome:WB:WBGene00006950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidase activity. Acts upstream of or within nematode male tail mating organ morphogenesis. Predicted to be located in cell surface; extracellular region; and plasma membrane. Predicted to be active in extracellular matrix. Is expressed in hyp10; hyp6; hyp7 syncytium; hyp8; and hyp9. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and solitary median maxillary central incisor. Orthologous to human SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See wrt-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (15752257..15757269, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class XA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene tRNA-Pro Neighboring gene Hexosyltransferase Neighboring gene FAD-binding PCMH-type domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Porter JA, et al. Cell, 1996 Jul 12. PMID 8689684
    2. Transcriptional repressor and activator activities of SMA-9 contribute differentially to BMP-related signaling outputs. Liang J, et al. Dev Biol, 2007 May 15. PMID 17397820
    3. Warthog and groundhog, novel families related to hedgehog. Bürglin TR. Curr Biol, 1996 Sep 1. PMID 8805384
    4. Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis. Aspöck G, et al. Genome Res, 1999 Oct. PMID 10523520
    5. Comprehensive analysis of gene expression patterns of hedgehog-related genes. Hao L, et al. BMC Genomics, 2006 Oct 31. PMID 17076889, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoprocessing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in segment polarity determination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Warthog protein 4 N-product
    NP_510593.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15752257..15757269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078192.9 → NP_510593.1  Warthog protein 4 N-product [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510593.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94129, Q94410
      Conserved Domains (2) summary
      cd00081
      Location:346 → 497
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
      pfam01079
      Location:342 → 547
      Hint; Hint module
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94129.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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