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    tmc-2 TMC domain-containing protein;Transmembrane channel-like protein 2 [ Caenorhabditis elegans ]

    Gene ID: 181161, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmc-2
    Official Full Name
    TMC domain-containing protein;Transmembrane channel-like protein 2
    Primary source
    WormBase:WBGene00015177
    Locus tag
    CELE_B0416.1
    See related
    AllianceGenome:WB:WBGene00015177
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Is expressed in body wall musculature and vulval muscle. Orthologous to human TMC3 (transmembrane channel like 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tmc-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    26
    Sequence:
    Chromosome: X; NC_003284.9 (9303722..9310443)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene TransThyretin-Related family domain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans. Yue X, et al. Neuron, 2018 Feb 7. PMID 29395910, Free PMC Article
    2. The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction. Clark S, et al. Proc Natl Acad Sci U S A, 2024 Feb 20. PMID 38354260, Free PMC Article
    3. tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans. Chatzigeorgiou M, et al. Nature, 2013 Feb 7. PMID 23364694, Free PMC Article
    4. The nematode C. elegans senses airborne sound. Iliff AJ, et al. Neuron, 2021 Nov 17. PMID 34555314, Free PMC Article
    5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
      Title: The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
    2. Study found that the C. elegans TMC-1 is expressed in both neurons and muscle cells, while TMC-2 is exclusively expressed in muscle cells. TMC proteins modulate egg laying and membrane excitability through a background leak conductance.
      Title: TMC Proteins Modulate Egg Laying and Membrane Excitability through a Background Leak Conductance in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TMC domain-containing protein;Transmembrane channel-like protein 2
    NP_001335510.1
    • Confirmed by transcript evidence
    NP_001335564.1
    • Confirmed by transcript evidence
    NP_001335565.1
    • Confirmed by transcript evidence
    NP_001335566.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9303722..9310443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348602.4 → NP_001335564.1  TMC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q11069
      UniProtKB/TrEMBL
      A0A1N7SYS6
      Conserved Domains (1) summary
      pfam07810
      Location:594 → 709
      TMC; TMC domain

    2. NM_001348601.5 → NP_001335510.1  Transmembrane channel-like protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q11069
      Conserved Domains (1) summary
      pfam07810
      Location:594 → 709
      TMC; TMC domain

    3. NM_001348603.4 → NP_001335565.1  TMC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SYT6
      Conserved Domains (1) summary
      pfam07810
      Location:294 → 409
      TMC; TMC domain

    4. NM_001348604.4 → NP_001335566.1  TMC domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1N7SZ06
      Conserved Domains (1) summary
      pfam07810
      Location:294 → 409
      TMC; TMC domain
    Nucleotide Protein
    Heading Accession and Version

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