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    dct-1 NIP3 homolog [ Caenorhabditis elegans ]

    Gene ID: 181053, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dct-1
    Official Full Name
    NIP3 homolog
    Primary source
    WormBase:WBGene00015776
    Locus tag
    CELE_C14F5.1
    See related
    AllianceGenome:WB:WBGene00015776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protease binding activity and protein homodimerization activity. Involved in several processes, including apoptotic process; determination of adult lifespan; and mitophagy. Located in mitochondrial outer membrane. Part of protein-containing complex. Is expressed in body wall musculature; intestine; neurons; pharynx; and vulval muscle. Orthologous to several human genes including BNIP3 (BCL2 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dct-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (7954354..7956225)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sidoreflexin Neighboring gene Sex muscle abnormal protein 5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coupling mitogenesis and mitophagy for longevity. Palikaras K, et al. Autophagy, 2015. PMID 26083448, Free PMC Article
    2. Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans. Leuthner TC, et al. Nucleic Acids Res, 2022 Aug 26. PMID 35947695, Free PMC Article
    3. A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan. Chamoli M, et al. Nat Aging, 2023 Dec. PMID 37957360, Free PMC Article
    4. The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism. Cizeau J, et al. Oncogene, 2000 Nov 16. PMID 11114722
    5. NAD(+) augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Fang EF, et al. Nat Commun, 2019 Nov 21. PMID 31754102, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial outer membrane permeabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of programmed cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NIP3 homolog
    NP_509339.4
    • Confirmed by transcript evidence
    NP_509340.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7954354..7956225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076939.5 → NP_509340.2  NIP3 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509340.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09969
      Conserved Domains (1) summary
      pfam06553
      Location:130 → 213
      BNIP3; BNIP3

    2. NM_076938.7 → NP_509339.4  NIP3 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509339.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09969, Q95QW5, Q9UB15
      Conserved Domains (1) summary
      pfam06553
      Location:133 → 216
      BNIP3; BNIP3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09969.2

    Gene LinkOut

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