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    cca-1 Voltage-dependent T-type calcium channel subunit alpha [ Caenorhabditis elegans ]

    Gene ID: 181045, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cca-1
    Official Full Name
    Voltage-dependent T-type calcium channel subunit alpha
    Primary source
    WormBase:WBGene00000367
    Locus tag
    CELE_C54D2.5
    See related
    AllianceGenome:WB:WBGene00000367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Involved in membrane depolarization; positive regulation of action potential; and regulation of nematode pharyngeal pumping. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in alimentary muscle; body wall musculature; distal tip cell; intestine; and nervous system. Human ortholog(s) of this gene implicated in cerebellar ataxia type 42; childhood absence epilepsy; primary hyperaldosteronism; and schizophrenia. Orthologous to several human genes including CACNA1I (calcium voltage-gated channel subunit alpha1 I). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cca-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    31
    Sequence:
    Chromosome: X; NC_003284.9 (7847678..7875954, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene EB domain-containing protein Neighboring gene ncRNA Neighboring gene DUF281 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DUF4440 domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans. Pandey R, et al. Seizure, 2010 Sep. PMID 20598917
    2. Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels. Zang KE, et al. Elife, 2017 Feb 6. PMID 28165324, Free PMC Article
    3. Sexually Dimorphic Neurotransmitter Release at the Neuromuscular Junction in Adult Caenorhabditis elegans. Yan Z, et al. Front Mol Neurosci, 2021. PMID 35173578, Free PMC Article
    4. Biophysical modeling of C. elegans neurons: Single ion currents and whole-cell dynamics of AWCon and RMD. Nicoletti M, et al. PLoS One, 2019. PMID 31260485, Free PMC Article
    5. A small-molecule screen in C. elegans yields a new calcium channel antagonist. Kwok TC, et al. Nature, 2006 May 4. PMID 16672971

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicate that T-type calcium channels are critical regulators of a Caenorhabditis elegans serotonergic circuit and demonstrate a mechanism in which T-type channels functionally gate inhibitory modulation in vivo.
      Title: Inhibitory peptidergic modulation of C. elegans serotonin neurons is gated by T-type calcium channels.
    2. We conclude that the CCA-1 T-type calcium channel boosts the excitatory effect of synaptic input, allowing for reliable and rapid depolarization and contraction of the pharyngeal muscle.
      Title: The C. elegans T-type calcium channel CCA-1 boosts neuromuscular transmission.
    3. Our results suggest that CCA-1's role is to accelerate the action potential upstroke in the pharyngeal muscle in response to excitatory inputs.
      Title: CCA-1, EGL-19 and EXP-2 currents shape action potentials in the Caenorhabditis elegans pharynx.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables low voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low voltage-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion import IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Voltage-dependent T-type calcium channel subunit alpha
    NP_001367690.1
    • Confirmed by transcript evidence
    NP_001367691.1
    • Confirmed by transcript evidence
    NP_001367692.1
    • Confirmed by transcript evidence
    NP_001368577.1
    • Confirmed by transcript evidence
    NP_001379830.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7847678..7875954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381031.2 → NP_001367690.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z002
      Conserved Domains (1) summary
      pfam00520
      Location:659 → 890
      Ion_trans; Ion transport protein

    2. NM_001381028.1 → NP_001367692.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZR6
      Conserved Domains (1) summary
      pfam00520
      Location:659 → 897
      Ion_trans; Ion transport protein

    3. NM_001381030.1 → NP_001367691.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z003
      Conserved Domains (1) summary
      pfam00520
      Location:1159 → 1430
      Ion_trans; Ion transport protein

    4. NM_001392802.1 → NP_001379830.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBS2
      Conserved Domains (1) summary
      pfam00520
      Location:659 → 890
      Ion_trans; Ion transport protein

    5. NM_001381029.1 → NP_001368577.1  Voltage-dependent T-type calcium channel subunit alpha [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASP4
      Conserved Domains (1) summary
      pfam00520
      Location:659 → 897
      Ion_trans; Ion transport protein
    Nucleotide Protein
    Heading Accession and Version

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