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    lgx-1 EGF-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180825, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgx-1
    Official Full Name
    EGF-like domain-containing protein
    Primary source
    WormBase:WBGene00002983
    Locus tag
    CELE_C54G7.3
    See related
    AllianceGenome:WB:WBGene00002983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. Predicted to be involved in carbohydrate metabolic process. Is expressed in somatic cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgx-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    31
    Sequence:
    Chromosome: X; NC_003284.9 (5525123..5538516, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene MBOAT family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pharyngeal polysaccharide deacetylases affect development in the nematode C. elegans and deacetylate chitin in vitro. Heustis RJ, et al. PLoS One, 2012. PMID 22808160, Free PMC Article
    2. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EGF-like domain-containing protein
    NP_001359928.1
    • Confirmed by transcript evidence
    NP_001360720.1
    • Confirmed by transcript evidence
    NP_001360721.1
    • Confirmed by transcript evidence
    NP_001360722.1
    • Confirmed by transcript evidence
    NP_001360723.1
    • Confirmed by transcript evidence
    NP_001360724.1
    • Confirmed by transcript evidence
    NP_001360725.1
    • Confirmed by transcript evidence
    NP_001360726.1
    • Confirmed by transcript evidence
    NP_741796.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5525123..5538516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373298.3 → NP_001359928.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ94
      Conserved Domains (3) summary
      smart00818
      Location:321 → 395
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd10974
      Location:1209 → 1484
      CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
      pfam01683
      Location:1090 → 1146
      EB; EB module

    2. NM_001373299.2 → NP_001360723.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK92
      Conserved Domains (3) summary
      smart00818
      Location:321 → 395
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd10974
      Location:1310 → 1585
      CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
      pfam01683
      Location:1191 → 1247
      EB; EB module

    3. NM_001373300.2 → NP_001360725.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INJ5
      Conserved Domains (3) summary
      PHA02682
      Location:337 → 442
      PHA02682; ORF080 virion core protein; Provisional
      cd10974
      Location:1257 → 1532
      CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
      pfam01683
      Location:1138 → 1194
      EB; EB module

    4. NM_001373301.2 → NP_001360721.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IM10
      Conserved Domains (3) summary
      PHA02682
      Location:337 → 442
      PHA02682; ORF080 virion core protein; Provisional
      cd10974
      Location:1358 → 1633
      CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
      pfam01683
      Location:1239 → 1295
      EB; EB module

    5. NM_001373302.2 → NP_001360726.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IND1
      Conserved Domains (3) summary
      smart00818
      Location:372 → 446
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd10974
      Location:1260 → 1535
      CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
      pfam01683
      Location:1141 → 1197
      EB; EB module

    6. NM_001373303.2 → NP_001360722.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKC9
      Conserved Domains (3) summary
      smart00818
      Location:372 → 446
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      cd10974
      Location:1361 → 1636
      CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
      pfam01683
      Location:1242 → 1298
      EB; EB module

    7. NM_001373304.2 → NP_001360724.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKS1
      Conserved Domains (3) summary
      PHA02682
      Location:388 → 493
      PHA02682; ORF080 virion core protein; Provisional
      cd10974
      Location:1308 → 1583
      CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
      pfam01683
      Location:1189 → 1245
      EB; EB module

    8. NM_001373305.2 → NP_001360720.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0ILL1
      Conserved Domains (3) summary
      PHA02682
      Location:388 → 493
      PHA02682; ORF080 virion core protein; Provisional
      cd10974
      Location:1409 → 1684
      CE4_CDA_like_1; Putative catalytic domain of chitin deacetylase-like proteins with additional chitin-binding peritrophin-A domain (ChBD) and/or a low-density lipoprotein receptor class A domain (LDLa)
      pfam01683
      Location:1290 → 1346
      EB; EB module

    9. NM_171690.6 → NP_741796.2  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741796.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFK4
      Conserved Domains (1) summary
      pfam01683
      Location:565 → 620
      EB; EB module
    Nucleotide Protein
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