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    hosl-1 Hormone-sensitive lipase [ Caenorhabditis elegans ]

    Gene ID: 180737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hosl-1
    Official Full Name
    Hormone-sensitive lipase
    Primary source
    WormBase:WBGene00016704
    Locus tag
    CELE_C46C11.1
    See related
    AllianceGenome:WB:WBGene00016704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sterol ester esterase activity and triacylglycerol lipase activity. Predicted to be involved in triglyceride catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including arcade cell; hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hosl-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (4637121..4643695)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SoLute Carrier family Related Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene Equilibrative nucleoside transporter 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans Perilipin Is Implicated in Cold-Induced Lipolysis and Inhibits Autophagy in Early Embryos. Kassak F, et al. Folia Biol (Praha), 2020. PMID 34087974
    2. Piceatannol Reduces Fat Accumulation in Caenorhabditis elegans. Shen P, et al. J Med Food, 2017 Sep. PMID 28514198, Free PMC Article
    3. The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans. Liu F, et al. Sci Rep, 2017 Apr 4. PMID 28377576, Free PMC Article
    4. Cranberry Product Decreases Fat Accumulation in Caenorhabditis elegans. Sun Q, et al. J Med Food, 2016 Apr. PMID 26991055, Free PMC Article
    5. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Narbonne P, et al. Nature, 2009 Jan 8. PMID 19052547

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol ester esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Hormone-sensitive lipase
    NP_001041228.1
    • Confirmed by transcript evidence
    NP_001367667.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4637121..4643695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047763.5 → NP_001041228.1  Hormone-sensitive lipase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q966P1
      Conserved Domains (3) summary
      COG0657
      Location:380 → 487
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:60 → 365
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:380 → 527
      Abhydrolase; alpha/beta hydrolases

    2. NM_001380950.1 → NP_001367667.1  Hormone-sensitive lipase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E7FM69
      Conserved Domains (2) summary
      pfam06350
      Location:25 → 330
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:345 → 452
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version

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