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    lipl-1 Lipase lipl-1 [ Caenorhabditis elegans ]

    Gene ID: 179771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lipl-1
    Official Full Name
    Lipase lipl-1
    Primary source
    WormBase:WBGene00010062
    Locus tag
    CELE_F54F3.3
    See related
    AllianceGenome:WB:WBGene00010062
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Involved in lipid catabolic process. Located in lysosome. Is expressed in intestine. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lipl-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (12919986..12921692)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Dehydrogenase/reductase SDR family member 4 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans. Buis A, et al. Cell Rep, 2019 Jul 23. PMID 31340142, Free PMC Article
    2. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. O'Rourke EJ, et al. Nat Cell Biol, 2013 Jun. PMID 23604316, Free PMC Article
    3. Surviving starvation simply without TFEB. Soukas AA, et al. PLoS Biol, 2019 May. PMID 31136567, Free PMC Article
    4. Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum. O'Rourke D, et al. Genome Res, 2006 Aug. PMID 16809667, Free PMC Article
    5. Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan. Oh M, et al. Sci Rep, 2022 May 3. PMID 35504961, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lipase lipl-1
    NP_506229.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12919986..12921692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073828.5 → NP_506229.1  Lipase lipl-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506229.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93789
      Conserved Domains (1) summary
      PLN02872
      Location:33 → 398
      PLN02872; triacylglycerol lipase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93789.2

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