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    che-11 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179666, updated on 9-Dec-2024

    Summary

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    Official Symbol
    che-11
    Official Full Name
    WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00000490
    Locus tag
    CELE_C27A7.4
    See related
    AllianceGenome:WB:WBGene00000490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including dauer entry; determination of adult lifespan; and positive regulation of intracellular transport. Located in non-motile cilium. Is expressed in body wall musculature; head; and neurons. Human ortholog(s) of this gene implicated in retinitis pigmentosa and short-rib thoracic dysplasia 9 with or without polydactyly. Orthologous to human IFT140 (intraflagellar transport 140). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See che-11 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    20
    Sequence:
    Chromosome: V; NC_003283.11 (12144244..12150707, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein Neighboring gene pseudo Neighboring gene Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 Neighboring gene ShKT domain-containing protein;Thrombospondin type 1 domain protein Neighboring gene ShKT domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Matching variants for functional characterization of genetic variants. Cevik S, et al. G3 (Bethesda), 2023 Dec 6. PMID 37933433, Free PMC Article
    2. Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans. Fujii M, et al. Biosci Biotechnol Biochem, 2005 Oct. PMID 16244463
    3. Single-Molecule Turnarounds of Intraflagellar Transport at the C. elegans Ciliary Tip. Mijalkovic J, et al. Cell Rep, 2018 Nov 13. PMID 30428341
    4. Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. Smith ED, et al. BMC Dev Biol, 2008 May 5. PMID 18457595, Free PMC Article
    5. An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons. Qin H, et al. Curr Biol, 2001 Mar 20. PMID 11301258

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cilium assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intraciliary retrograde transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of intraciliary anterograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intraciliary retrograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle A IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle A ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD_REPEATS_REGION domain-containing protein
    NP_506047.5
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12144244..12150707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073646.7 → NP_506047.5  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506047.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90757
      Conserved Domains (2) summary
      COG0790
      Location:841 → 1053
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00006
      Location:934 → 960
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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