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    R04B5.5 Sorbitol dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 179405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    R04B5.5
    Official Full Name
    Sorbitol dehydrogenase
    Primary source
    WormBase:WBGene00011003
    Locus tag
    CELE_R04B5.5
    See related
    AllianceGenome:WB:WBGene00011003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable L-iditol 2-dehydrogenase (NAD+) activity. Predicted to be involved in sorbitol catabolic process. Is expressed in body wall musculature and intestine. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See R04B5.5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (10087480..10089002)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-12;Nuclear receptor Neighboring gene Sorbitol dehydrogenase Neighboring gene BHLH domain-containing protein Neighboring gene Transposase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-iditol 2-dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sorbitol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sorbitol dehydrogenase
    NP_505591.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10087480..10089002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073190.5 → NP_505591.1  Sorbitol dehydrogenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505591.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21702
      Conserved Domains (1) summary
      cd05285
      Location:7 → 347
      sorbitol_DH; Sorbitol dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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