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    clic-1 Clathrin light chain [ Caenorhabditis elegans ]

    Gene ID: 179150, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clic-1
    Official Full Name
    Clathrin light chain
    Primary source
    WormBase:WBGene00020246
    Locus tag
    CELE_T05B11.3
    See related
    AllianceGenome:WB:WBGene00020246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable clathrin heavy chain binding activity. Predicted to be involved in clathrin-dependent endocytosis. Located in periciliary membrane compartment. Is expressed in head; nervous system; and pharynx. Orthologous to several human genes including CLTA (clathrin light chain A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clic-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (7733624..7734911, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein;Secreted protein Neighboring gene tRNA-Thr Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class R Neighboring gene Gustatory receptor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex. Holmes A, et al. J Cell Sci, 2007 Aug 1. PMID 17636000
    2. Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8. Shi A, et al. EMBO J, 2009 Nov 4. PMID 19763082, Free PMC Article
    3. Claudin family proteins in Caenorhabditis elegans. Simske JS, et al. Methods Mol Biol, 2011. PMID 21717355
    4. RNAi screen of DAF-16/FOXO target genes in C. elegans links pathogenesis and dauer formation. Jensen VL, et al. PLoS One, 2010 Dec 31. PMID 21209831, Free PMC Article
    5. Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. Poteryaev D, et al. EMBO J, 2007 Jan 24. PMID 17203072, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of SNX-1, RME-8, or the clathrin chaperone Hsc70/HSP-1 leads to over-accumulation of endosomal clathrin, reduced clathrin dynamics, and missorting of MIG-14 to the lysosome.
      Title: Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin coat of coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin coat of trans-Golgi network vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periciliary membrane compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic endocytic zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Clathrin light chain
    NP_504999.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7733624..7734911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072598.8 → NP_504999.1  Clathrin light chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504999.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P90961
      Conserved Domains (1) summary
      pfam01086
      Location:2 → 222
      Clathrin_lg_ch; Clathrin light chain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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