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    pid-5 Protein pid-5 [ Caenorhabditis elegans ]

    Gene ID: 178819, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pid-5
    Official Full Name
    Protein pid-5
    Primary source
    WormBase:WBGene00021555
    Locus tag
    CELE_Y45G5AM.2
    See related
    AllianceGenome:WB:WBGene00021555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aminopeptidase activity. Predicted to be involved in regulatory ncRNA-mediated gene silencing. Predicted to be located in P-body and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to several human genes including XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pid-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (4175882..4181360)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene FBA_2 domain-containing protein Neighboring gene Cilia- and flagella-associated protein 157 Neighboring gene Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein Neighboring gene Aftiphilin clathrin-binding box domain-containing protein;Clathrin_bdg domain-containing protein;Transcription factor Neighboring gene Nuclear hormone receptor 114 Neighboring gene Dolichyl-phosphate beta-glucosyltransferase;dolichyl-phosphate beta-glucosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Molecular Analysis of the Aminopeptidase P-Related Domain of PID-5 from Caenorhabditis elegans. Lloyd AC, et al. Biomolecules, 2023 Jul 14. PMID 37509168, Free PMC Article
    2. Intrinsically disordered protein PID-2 modulates Z granules and is required for heritable piRNA-induced silencing in the Caenorhabditis elegans embryo. Placentino M, et al. EMBO J, 2021 Feb 1. PMID 33231880, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Molecular Analysis of the Aminopeptidase P-Related Domain of PID-5 from Caenorhabditis elegans.
      Title: A Molecular Analysis of the Aminopeptidase P-Related Domain of PID-5 from Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein pid-5
    NP_001317846.1
    • Confirmed by transcript evidence
    NP_001317847.1
    • Confirmed by transcript evidence
    NP_504162.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4175882..4181360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071761.6 → NP_504162.2  Protein pid-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504162.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A163VU95, A0A168HAZ2, Q9GUI6
      Conserved Domains (4) summary
      cd01085
      Location:772 → 996
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:998 → 1061
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:630 → 766
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:498 → 606
      Creatinase_N; Creatinase/Prolidase N-terminal domain

    2. NM_001330835.3 → NP_001317846.1  Protein pid-5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A163VU95

    3. NM_001330836.3 → NP_001317847.1  Protein pid-5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A168HAZ2

    RNA

    1. NR_138522.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GUI6.3

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