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    frm-5.1 FERM domain (Protein4.1-ezrin-radixin-moesin) family;Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176822, updated on 9-Dec-2024

    Summary

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    Official Symbol
    frm-5.1
    Official Full Name
    FERM domain (Protein4.1-ezrin-radixin-moesin) family;Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00001492
    Locus tag
    CELE_Y38C1AB.8
    See related
    AllianceGenome:WB:WBGene00001492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable kinase activity. Orthologous to human FRMPD2 (FERM and PDZ domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See frm-5.1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    22
    Sequence:
    Chromosome: IV; NC_003282.8 (32463..48880, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein containing ALS2cr12 (ALS2CR12) signature Neighboring gene Ion transport domain-containing protein Neighboring gene N-acetylgalactosaminide beta-1,3-galactosyltransferase Neighboring gene ncRNA Neighboring gene DUF3899 domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden D, et al. Dev Biol, 2004 Aug 1. PMID 15242805
    2. A specificity map for the PDZ domain family. Tonikian R, et al. PLoS Biol, 2008 Sep 30. PMID 18828675, Free PMC Article
    3. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FERM domain (Protein4.1-ezrin-radixin-moesin) family;Protein kinase domain-containing protein
    NP_001255216.1
    • Confirmed by transcript evidence
    NP_001255217.2
    • Confirmed by transcript evidence
    NP_001408266.1
    • Confirmed by transcript evidence
    NP_001408267.1
    • Confirmed by transcript evidence
    NP_001408268.1
    • Confirmed by transcript evidence
    NP_001408269.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      32463..48880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268288.4 → NP_001255217.2  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255217.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4RT84, Q33BL4
      Conserved Domains (6) summary
      smart00295
      Location:686 → 891
      B41; Band 4.1 homologues
      cd00992
      Location:1113 → 1194
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13187
      Location:887 → 1002
      FERM_C_PTPH13; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor 13 (PTPH13)
      pfam00373
      Location:781 → 891
      FERM_M; FERM central domain
      pfam09379
      Location:689 → 751
      FERM_N; FERM N-terminal domain
      cl21453
      Location:9 → 164
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001421336.1 → NP_001408267.1  FERM domain (Protein4.1-ezrin-radixin-moesin) family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QC08

    3. NM_001268287.2 → NP_001255216.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8W3Y2
      Conserved Domains (6) summary
      smart00295
      Location:686 → 891
      B41; Band 4.1 homologues
      cd00992
      Location:1127 → 1208
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00373
      Location:781 → 891
      FERM_M; FERM central domain
      pfam09379
      Location:689 → 751
      FERM_N; FERM N-terminal domain
      cl17171
      Location:887 → 1016
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:9 → 164
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001421337.1 → NP_001408266.1  FERM domain (Protein4.1-ezrin-radixin-moesin) family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QDD1

    5. NM_001421338.1 → NP_001408269.1  FERM domain (Protein4.1-ezrin-radixin-moesin) family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QGP1

    6. NM_001421339.1 → NP_001408268.1  FERM domain (Protein4.1-ezrin-radixin-moesin) family [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QCJ3
    Nucleotide Protein
    Heading Accession and Version

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