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    exo-1 Exonuclease 1 [ Caenorhabditis elegans ]

    Gene ID: 176765, updated on 9-Dec-2024

    Summary

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    Official Symbol
    exo-1
    Official Full Name
    Exonuclease 1
    Primary source
    WormBase:WBGene00009731
    Locus tag
    CELE_F45G2.3
    See related
    AllianceGenome:WB:WBGene00009731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5'-3' DNA exonuclease activity and 5'-flap endonuclease activity. Predicted to be involved in DNA recombination and mismatch repair. Predicted to be active in nucleus. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See exo-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (13423514..13426204)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Myosin motor domain-containing protein;Myosin_tail_1 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Coatomer subunit epsilon Neighboring gene Kunitz-type protein bli-5 Neighboring gene TNF Receptor Associated Factor (TRAF) homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impaired resection of meiotic double-strand breaks channels repair to nonhomologous end joining in Caenorhabditis elegans. Yin Y, et al. Mol Cell Biol, 2013 Jul. PMID 23671188, Free PMC Article
    2. Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis. Hicks T, et al. Cell Rep, 2022 Sep 27. PMID 36170820
    3. The Caenorhabditis elegans WRN helicase promotes double-strand DNA break repair by mediating end resection and checkpoint activation. Ryu JS, et al. FEBS Lett, 2017 Jul. PMID 28640365
    4. COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining. Lemmens BB, et al. PLoS Genet, 2013. PMID 23408909, Free PMC Article
    5. Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans. Bae W, et al. FEBS J, 2020 Mar. PMID 31593615

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans.
      Title: Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Exonuclease 1
    NP_499770.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13423514..13426204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067369.5 → NP_499770.1  Exonuclease 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499770.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62245
      Conserved Domains (2) summary
      cd09908
      Location:219 → 298
      H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
      cd09857
      Location:1 → 205
      PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    Nucleotide Protein
    Heading Accession and Version

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