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    php-3 Homeobox protein php-3 [ Caenorhabditis elegans ]

    Gene ID: 176640, updated on 9-Dec-2024

    Summary

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    Official Symbol
    php-3
    Official Full Name
    Homeobox protein php-3
    Primary source
    WormBase:WBGene00004024
    Locus tag
    CELE_Y75B8A.1
    See related
    AllianceGenome:WB:WBGene00004024
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of nematode male tail tip morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including coelomocyte; head neurons; intestine; somatic nervous system; and tail neurons. Human ortholog(s) of this gene implicated in congenital vertical talus. Orthologous to several human genes including HOXC10 (homeobox C10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See php-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (12074218..12077556, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Actin-related protein 2/3 complex subunit Neighboring gene Serine/threonine-protein kinase zyg-8;non-specific serine/threonine protein kinase Neighboring gene Homeobox protein nob-1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Introduction to nematode evolution and ecology. Fitch DH. WormBook, 2005 Aug 31. PMID 18050395, Free PMC Article
    2. Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes. Van Auken K, et al. Proc Natl Acad Sci U S A, 2000 Apr 25. PMID 10781051, Free PMC Article
    3. Hox Gene Loss during Dynamic Evolution of the Nematode Cluster. Aboobaker AA, et al. Curr Biol, 2003 Jan 8. PMID 12526742
    4. Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans. Zheng C, et al. Neuron, 2015 Nov 4. PMID 26539892, Free PMC Article
    5. Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis. Van Auken K, et al. Development, 2002 Nov. PMID 12399316

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein php-3
    NP_499573.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12074218..12077556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067172.7 → NP_499573.1  Homeobox protein php-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499573.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U9C3, Q9XW88
      Conserved Domains (1) summary
      pfam00046
      Location:202 → 256
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XW88.2

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