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    exos-1 Exosome complex component CSL4 homolog [ Caenorhabditis elegans ]

    Gene ID: 176532, updated on 9-Dec-2024

    Summary

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    Official Symbol
    exos-1
    Official Full Name
    Exosome complex component CSL4 homolog
    Primary source
    WormBase:WBGene00012966
    Locus tag
    CELE_Y48A6B.5
    See related
    AllianceGenome:WB:WBGene00012966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in rRNA processing. Located in cytoplasm and nucleus. Is expressed in several structures, including head; intestine; and nervous system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1F. Orthologous to human EXOSC1 (exosome component 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See exos-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (11009043..11010588)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Putative H/ACA ribonucleoprotein complex subunit 2-like protein Neighboring gene BTB domain-containing protein;putative voltage-gated potassium channel subunit kvs-4 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos. Gallo CM, et al. Dev Biol, 2008 Nov 1. PMID 18692039
    2. A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans. Xu T, et al. PLoS Genet, 2023 Feb. PMID 36763670, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Exosome complex component CSL4 homolog
    NP_499416.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11009043..11010588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067015.8 → NP_499416.1  Exosome complex component CSL4 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499416.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XXD2
      Conserved Domains (1) summary
      COG1096
      Location:5 → 195
      Csl4; Exosome complex RNA-binding protein Csl4, contains S1 and Zn-ribbon domains [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XXD2.1

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