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    cor-1 Coronin-like protein cor-1 [ Caenorhabditis elegans ]

    Gene ID: 176440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cor-1
    Official Full Name
    Coronin-like protein cor-1
    Primary source
    WormBase:WBGene00000768
    Locus tag
    CELE_R01H10.3
    See related
    AllianceGenome:WB:WBGene00000768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including QL; QL.a; QL.p; QR; and oxygen sensory neurons. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Orthologous to several human genes including CORO1A (coronin 1A); CORO1B (coronin 1B); and CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cor-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (10249111..10254709)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein Neighboring gene Solute carrier organic anion transporter family member Neighboring gene DNA polymerase alpha subunit B Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene RFS-1 Interacting Partner Neighboring gene BBSome complex member bbs-5 Neighboring gene PH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conditional targeted genome editing using somatically expressed TALENs in C. elegans. Cheng Z, et al. Nat Biotechnol, 2013 Oct. PMID 23955274
    2. Caenorhabditis elegans Flamingo FMI-1 controls dendrite self-avoidance through F-actin assembly. Hsu HW, et al. Development, 2020 Jul 31. PMID 32631831
    3. RTKN-1/Rhotekin shields endosome-associated F-actin from disassembly to ensure endocytic recycling. Yan Y, et al. J Cell Biol, 2021 May 3. PMID 33844824, Free PMC Article
    4. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. Waaijers S, et al. BMC Biol, 2016 Aug 9. PMID 27506200, Free PMC Article
    5. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Coronin-like protein cor-1
    NP_741268.1
    • Confirmed by transcript evidence
    NP_741269.1
    • Confirmed by transcript evidence
    NP_741270.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10249111..10254709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171226.5 → NP_741268.1  Coronin-like protein cor-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21624, Q8T3D5, Q8T3D6, Q8T3D7
      Conserved Domains (5) summary
      pfam08953
      Location:6 → 62
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:344 → 383
      WD40_4; Type of WD40 repeat
      pfam16612
      Location:414 → 511
      RGS12_usC; C-terminal unstructured region of RGS12
      sd00039
      Location:38 → 76
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_171893.6 → NP_741270.1  Coronin-like protein cor-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21624
      Conserved Domains (5) summary
      PTZ00421
      Location:8 → 530
      PTZ00421; coronin; Provisional
      pfam08953
      Location:6 → 62
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:344 → 383
      WD40_4; Type of WD40 repeat
      sd00039
      Location:38 → 76
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_171892.8 → NP_741269.1  Coronin-like protein cor-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741269.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21624
      Conserved Domains (5) summary
      pfam08953
      Location:6 → 62
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:344 → 383
      WD40_4; Type of WD40 repeat
      pfam16612
      Location:414 → 511
      RGS12_usC; C-terminal unstructured region of RGS12
      sd00039
      Location:38 → 76
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21624.2

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