tbp-1 TATA-box-binding protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tbp-1
Official Full Name: TATA-box-binding protein
Primary source: WormBase:WBGene00006542
Locus tag: CELE_T20B12.2
See related: AllianceGenome:WB:WBGene00006542
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor activity; RNA polymerase II general transcription initiation factor binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in gonad. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; schizophrenia; spinocerebellar ataxia type 17; and type 1 diabetes mellitus. Orthologous to human TBP (TATA-box binding protein) and TBPL2 (TATA-box binding protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tbp-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (7384033..7386124)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T20B12.3 (e-PCR)
- UniSTS:306282

T20B12.2 (e-PCR)
- UniSTS:310898

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase III general transcription initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables TFIIA-class transcription factor complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables TFIIB-class transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables minor groove of adenine-thymine-rich DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIID complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TATA-box-binding protein

NP_001370645.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7384033..7386124

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382915.2 → NP_001370645.1 TATA-box-binding protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P32085

Conserved Domains (1) summary

cd04516
Location:165 → 338

TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...