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    prk-1 non-specific serine/threonine protein kinase [ Caenorhabditis elegans ]

    Gene ID: 175980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prk-1
    Official Full Name
    non-specific serine/threonine protein kinase
    Primary source
    WormBase:WBGene00004182
    Locus tag
    CELE_C06E8.3
    See related
    AllianceGenome:WB:WBGene00004182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in negative regulation of apoptotic process and regulation of mitotic cell cycle. Predicted to be active in cytoplasm. Is expressed in intestine and nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See prk-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (6990168..7002310)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Homeobox protein ceh-20 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lipid-binding serum glycoprotein C-terminal domain-containing protein Neighboring gene Gamma-aminobutyric acid receptor subunit beta Neighboring gene ncRNA Neighboring gene Cuticle collagen 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rte-1, a retrotransposon-like element in Caenorhabditis elegans. Youngman S, et al. FEBS Lett, 1996 Feb 12. PMID 8603714
    2. PIM-Related Kinases Selectively Regulate Olfactory Sensations in Caenorhabditis elegans. Kalichamy KS, et al. eNeuro, 2019 Jul/Aug. PMID 31387876, Free PMC Article
    3. Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposon insertion mutant bank. Zwaal RR, et al. Proc Natl Acad Sci U S A, 1993 Aug 15. PMID 8395047, Free PMC Article
    4. Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. Trachtulec Z, et al. Mamm Genome, 2001 Mar. PMID 11252172
    5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    non-specific serine/threonine protein kinase
    NP_001263706.1
    • Confirmed by transcript evidence
    NP_001364690.1
    • Confirmed by transcript evidence
    NP_001364691.1
    • Confirmed by transcript evidence
    NP_498528.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6990168..7002310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276777.4 → NP_001263706.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263706.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8ESD7
      Conserved Domains (1) summary
      cd14005
      Location:56 → 309
      STKc_PIM; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase

    2. NM_001377564.1 → NP_001364690.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYI1
      Conserved Domains (1) summary
      cd14005
      Location:33 → 286
      STKc_PIM; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase

    3. NM_001377565.2 → NP_001364691.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3F1
      Conserved Domains (1) summary
      cd14005
      Location:33 → 286
      STKc_PIM; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase

    4. NM_066127.5 → NP_498528.1  non-specific serine/threonine protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYI2
      Conserved Domains (1) summary
      cl21453
      Location:33 → 199
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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