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    pdf-1 Pigment dispersing factor homolog pdf-1 [ Caenorhabditis elegans ]

    Gene ID: 175963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pdf-1
    Official Full Name
    Pigment dispersing factor homolog pdf-1
    Primary source
    WormBase:WBGene00020317
    Locus tag
    CELE_T07E3.6
    See related
    AllianceGenome:WB:WBGene00020317
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including locomotion involved in locomotory behavior; locomotor rhythm; and locomotory exploration behavior. Predicted to be located in extracellular region. Is expressed in neurons and rectum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pdf-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (6909590..6912266, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene DSBA-like thioredoxin domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Leucine-rich repeat flightless-interacting protein 2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A proteomic approach to neuropeptide function elucidation. Temmerman L, et al. Peptides, 2012 Mar. PMID 21920396
    2. Glia-derived neurons are required for sex-specific learning in C. elegans. Sammut M, et al. Nature, 2015 Oct 15. PMID 26469050, Free PMC Article
    3. A structural and functional comparison of nematode and crustacean PDH-like sequences. Meelkop E, et al. Peptides, 2012 Mar. PMID 22115566
    4. frpr-18, a neuropeptide receptor, regulates organismal lifespan and stress tolerance in C. elegans. Ouaakki H, et al. MicroPubl Biol, 2023. PMID 37383174, Free PMC Article
    5. Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans. Janssen T, et al. J Biol Chem, 2008 May 30. PMID 18390545, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In Drosophila, the ion channel narrow abdomen, an ortholog of the C. elegans NCA channels, drive the pigment dispersing factor (PDF) neuropeptide release, regulating circadian behavior. However, in C. elegans, we found that loss of the PDF receptor PDFR-1 did not suppress gain-of-function sleep defects, suggesting an alternative downstream pathway.
      Title: Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans.
    2. PDF-1 signaling acts sex- and cell-specifically in the ASJ neurons to regulate the expression of daf-7.
      Title: PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans.
    3. we have studied the role of the PDF neuropeptide in the circadian system of C. elegans
      Title: Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans.
    4. Pigment dispersing factor receptor (PDFR)-1 and its ligand PDF-1 stimulate mate searching in the male, but not in the hermaphrodite.
      Title: PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in parturition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sleep IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pigment dispersing factor homolog pdf-1
    NP_001379990.1
    • Confirmed by transcript evidence
    NP_741206.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6909590..6912266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171878.7 → NP_741206.2  Pigment dispersing factor homolog pdf-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B2BBX9, G5EEV3, G8JYC6, Q8WQD1

    2. NM_001392134.1 → NP_001379990.1  Pigment dispersing factor homolog pdf-1 [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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