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    rabn-5 FYVE-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175823, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rabn-5
    Official Full Name
    FYVE-type domain-containing protein
    Primary source
    WormBase:WBGene00017161
    Locus tag
    CELE_F01F1.4
    See related
    AllianceGenome:WB:WBGene00017161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activating protein binding activity. Involved in molting cycle. Orthologous to several human genes including RABEP1 (rabaptin, RAB GTPase binding effector protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rabn-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5864553..5866541)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative aldehyde dehydrogenase family 7 member A1 homolog Neighboring gene Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein Neighboring gene Aspartyl aminopeptidase Neighboring gene mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase Neighboring gene DUF3456 domain-containing protein Neighboring gene PAP-associated domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Wang Y, et al. Nature, 1997 Aug 7. PMID 9252191
    2. RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. Sasidharan N, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23100538, Free PMC Article
    3. Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit. Sato M, et al. Nat Cell Biol, 2005 Jun. PMID 15895077, Free PMC Article
    4. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    5. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FYVE-type domain-containing protein
    NP_498266.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5864553..5866541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065865.7 → NP_498266.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498266.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19088
      Conserved Domains (2) summary
      cd15739
      Location:338 → 410
      FYVE_RABE_unchar; FYVE domain found in uncharacterized rab GTPase-binding effector proteins from bilateria
      pfam09311
      Location:37 → 336
      Rab5-bind; Rabaptin-like protein
    Nucleotide Protein
    Heading Accession and Version

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