daf-4 Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: daf-4
Official Full Name: Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase
Primary source: WormBase:WBGene00000900
Locus tag: CELE_C05D2.1
See related: AllianceGenome:WB:WBGene00000900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables BMP binding activity. Involved in several processes, including dauer entry; defense response to other organism; and regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including ganglia; intestine; somatic nervous system; tail hypodermis; and vulva. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; Lynch syndrome (multiple); Marfan syndrome; gastrointestinal system cancer (multiple); and mismatch repair cancer syndrome. Orthologous to several human genes including ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See daf-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 11

Sequence:: Chromosome: III; NC_003281.10 (5625135..5632322)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSP-12 and TSP-14 are required for the recycling of DAF-4/BMPRII.
Title: Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans.
Our mutant daf-4 nematode models of Marfan syndrome (MFS) suggest that MFS and MFS-like mutations in the TGFB type II receptor lead to mis-trafficking of the receptor and possibly provides an explanation for the disease, a phenomenon which might also occur in some cancers that possess the same mutations within the type II receptor (e.g. colon cancer).
Title: Human Marfan and Marfan-like Syndrome associated mutations lead to altered trafficking of the Type II TGFβ receptor in Caenorhabditis elegans.
isolated dauer-formation mutations in C. briggsae, a species closely related to the model organism C. elegans and identified mutations in orthologs of C. elegans genes daf-2, daf-3 and daf-4
Title: Genetic analysis of dauer formation in Caenorhabditis briggsae.
alternative polyadenylation in intron 5 of daf-4 results in a 2.0 kb mRNA that encodes an open reading frame including only the N-terminal secretion signal and ligand-binding domains, and not the transmembrane or kinase domains
Title: Alternative polyadenylation results in a truncated daf-4 BMP receptor that antagonizes DAF-7-mediated development in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS3-145 (e-PCR)
- UniSTS:241985

C05D2.1 (e-PCR)
- UniSTS:308467

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables BMP binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IC Inferred by Curator more info	PubMed
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mesodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase

NP_001021149.1

Confirmed by transcript evidence

NP_001309588.1

Confirmed by transcript evidence

NP_001317770.1

Confirmed by transcript evidence

NP_001379620.1

Confirmed by transcript evidence

NP_498211.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5625135..5632322

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001322590.4 → NP_001309588.1 Serine/threonine-protein kinase receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MB12

Conserved Domains (3) summary

smart00220
Location:289 → 569

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam01684
Location:146 → 192

ET; ET module

cl21453
Location:289 → 582

PKc_like; Protein Kinases, catalytic domain
NM_001392102.1 → NP_001379620.1 Serine/threonine-protein kinase receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8ITX8

Conserved Domains (1) summary

cl21453
Location:158 → 451

PKc_like; Protein Kinases, catalytic domain
NM_065810.8 → NP_498211.1 Cell surface receptor daf-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498211.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45139, P50488

Conserved Domains (3) summary

smart00220
Location:310 → 590

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam01684
Location:146 → 192

ET; ET module

cl21453
Location:310 → 603

PKc_like; Protein Kinases, catalytic domain
NM_001025978.3 → NP_001021149.1 receptor protein serine/threonine kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021149.1

Status: REVIEWED

UniProtKB/TrEMBL

G8JY02

Conserved Domains (2) summary

pfam01684
Location:146 → 192

ET; ET module

cl21453
Location:310 → 445

PKc_like; Protein Kinases, catalytic domain
NM_001330884.3 → NP_001317770.1 receptor protein serine/threonine kinase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A131MBJ8