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    F09F7.5 CRIB domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F09F7.5
    Official Full Name
    CRIB domain-containing protein
    Primary source
    WormBase:WBGene00017302
    Locus tag
    CELE_F09F7.5
    See related
    AllianceGenome:WB:WBGene00017302
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in regulation of Rho protein signal transduction and regulation of cell shape. Predicted to be located in cytoskeleton and plasma membrane. Orthologous to human CDC42SE1 (CDC42 small effector 1) and CDC42SE2 (CDC42 small effector 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F09F7.5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (5547032..5551215)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene putative kinase-like protein D1044.1 Neighboring gene Ferritin Neighboring gene DNA N6-methyl adenine demethylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CRIB domain-containing protein
    NP_001379844.1
    • Confirmed by transcript evidence
    NP_498186.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5547032..5551215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392099.1 → NP_001379844.1  CRIB domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZJ0
      Conserved Domains (2) summary
      smart00285
      Location:22 → 56
      PBD; P21-Rho-binding domain
      PRK14965
      Location:298 → 390
      PRK14965; DNA polymerase III subunits gamma and tau; Provisional

    2. NM_065785.8 → NP_498186.1  CRIB domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498186.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19275
      Conserved Domains (2) summary
      smart00285
      Location:22 → 56
      PBD; P21-Rho-binding domain
      PRK14965
      Location:299 → 391
      PRK14965; DNA polymerase III subunits gamma and tau; Provisional
    Nucleotide Protein
    Heading Accession and Version

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