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    atf-7 Transcription factor atf-7 [ Caenorhabditis elegans ]

    Gene ID: 175587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atf-7
    Official Full Name
    Transcription factor atf-7
    Primary source
    WormBase:WBGene00000223
    Locus tag
    CELE_C07G2.2
    See related
    AllianceGenome:WB:WBGene00000223
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and mitogen-activated protein kinase binding activity. Involved in several processes, including defense response to bacterium; regulation of innate immune response; and regulation of transcription by RNA polymerase II. Acts upstream of or within serotonin biosynthetic process. Located in chromatin and nucleus. Is expressed in body wall musculature; hypodermis; intestine; neurons; and rectal epithelial cell. Orthologous to human ATF2 (activating transcription factor 2); ATF7 (activating transcription factor 7); and CREB5 (cAMP responsive element binding protein 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See atf-7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (4491627..4499045, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Insulin-like peptide 17 Neighboring gene Chondroitin proteoglycan 1 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene T-complex protein 1 subunit epsilon Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation. Huang Y, et al. Aging Dis, 2023 Aug 1. PMID 37163432, Free PMC Article
    2. Global transcriptional regulation of innate immunity by ATF-7 in C. elegans. Fletcher M, et al. PLoS Genet, 2019 Feb. PMID 30789901, Free PMC Article
    3. An essential role for XBP-1 in host protection against immune activation in C. elegans. Richardson CE, et al. Nature, 2010 Feb 25. PMID 20182512, Free PMC Article
    4. The Developmental Intestinal Regulator ELT-2 Controls p38-Dependent Immune Responses in Adult C. elegans. Block DH, et al. PLoS Genet, 2015 May. PMID 26016853, Free PMC Article
    5. Impacts of konjac glucomannan with different degree of degradation or deacetylation on the stress resistance and fitness in Caenorhabditis elegans. Cao X, et al. Int J Biol Macromol, 2022 Apr 15. PMID 35114273

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response.
      Title: Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response.
    2. Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1.
      Title: Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1.
    3. Study shows that ATF-7 regulates a majority of all genes induced by pathogen infection by occupancy in their regulatory regions in a PMK-1-dependent manner. Moreover, a subset of these ATF-7-regulated pathogen-induced target genes supports a direct role for this transcriptional response in host defense. Overall, data suggest that ATF-7 is a direct regulator of immune effector genes that is regulated by PMK-1 p38 MAPK.
      Title: Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.
    4. The p38MAPK/ATF-7 immune pathway is triggered by mitochondrial complex I dysfunction.
      Title: The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective.
    5. ATF-7 was identified in both ethylmethanesulfonate mutagenesis and candidate gene screens
      Title: Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.
    6. Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans
      Title: Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cAMP response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within serotonin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription factor atf-7
    NP_001370161.1
    • Confirmed by transcript evidence
    NP_001379489.1
    • Confirmed by transcript evidence
    NP_497913.1
    • Confirmed by transcript evidence
    NP_497914.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4491627..4499045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065513.5 → NP_497914.2  Transcription factor atf-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497914.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3R1
      Conserved Domains (2) summary
      smart00338
      Location:340 → 404
      BRLZ; basic region leucin zipper
      cd14687
      Location:345 → 396
      bZIP_ATF2; coiled coil [structural motif]

    2. NM_001393322.1 → NP_001379489.1  Transcription factor atf-7 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00338
      Location:321 → 372
      BRLZ; basic region leucin zipper
      cd14687
      Location:326 → 372
      bZIP_ATF2; coiled coil [structural motif]

    3. NM_065512.5 → NP_497913.1  Transcription factor atf-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17801
      Conserved Domains (2) summary
      smart00338
      Location:340 → 407
      BRLZ; basic region leucin zipper
      cd14687
      Location:345 → 399
      bZIP_ATF2; coiled coil [structural motif]

    4. NM_001384076.2 → NP_001370161.1  Transcription factor atf-7 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3GWA6, Q17801, Q86MD3, Q9U3R1
      Conserved Domains (2) summary
      smart00338
      Location:389 → 456
      BRLZ; basic region leucin zipper
      cd14687
      Location:394 → 448
      bZIP_ATF2; coiled coil [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86MD3.1

    Gene LinkOut

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