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    evl-14 Cnd1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    evl-14
    Official Full Name
    Cnd1 domain-containing protein
    Primary source
    WormBase:WBGene00001352
    Locus tag
    CELE_H38K22.1
    See related
    AllianceGenome:WB:WBGene00001352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in meiotic sister chromatid cohesion and mitotic sister chromatid cohesion. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human PDS5A (PDS5 cohesin associated factor A) and PDS5B (PDS5 cohesin associated factor B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See evl-14 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    21
    Sequence:
    Chromosome: III; NC_003281.10 (4303096..4313128, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene GP-PDE domain-containing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase Neighboring gene Defective in cullin neddylation protein 1 Neighboring gene ncRNA Neighboring gene Neuferricin homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis. Wang F, et al. Mol Cell Biol, 2003 Nov. PMID 14560015, Free PMC Article
    2. The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins. Kim Y, et al. Dev Cell, 2014 Nov 24. PMID 25446517, Free PMC Article
    3. ATM signaling modulates cohesin behavior in meiotic prophase and proliferating cells. Yu Z, et al. Nat Struct Mol Biol, 2023 Apr. PMID 36879153, Free PMC Article
    4. Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development. Simonet T, et al. Dev Biol, 2007 Dec 1. PMID 17967446
    5. Isolation and characterization of mutations causing abnormal eversion of the vulva in Caenorhabditis elegans. Seydoux G, et al. Dev Biol, 1993 Jun. PMID 8500652

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cnd1 domain-containing protein
    NP_497865.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4303096..4313128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065464.9 → NP_497865.2  Cnd1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497865.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC05
      Conserved Domains (1) summary
      PTZ00449
      Location:1333 → 1524
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    Nucleotide Protein
    Heading Accession and Version

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