grk-2 G protein-coupled receptor kinase 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: grk-2
Official Full Name: G protein-coupled receptor kinase 2
Primary source: WormBase:WBGene00001709
Locus tag: CELE_W02B3.2
See related: AllianceGenome:WB:WBGene00001709
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled receptor binding activity and G protein-coupled receptor kinase activity. Involved in several processes, including positive regulation of egg-laying behavior; positive regulation of growth rate; and serotonin catabolic process. Is expressed in neurons and vulval muscle. Orthologous to human GRK2 (G protein-coupled receptor kinase 2) and GRK3 (G protein-coupled receptor kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See grk-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (676122..680658)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G protein-coupled receptor kinase-2 (GRK-2) controls exploration through neuropeptide signaling in Caenorhabditis elegans.
Title: G protein-coupled receptor kinase-2 (GRK-2) controls exploration through neuropeptide signaling in Caenorhabditis elegans.
G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress.
Title: G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress.
G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.
Title: G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses.
Genetic epistasis experiments suggest that GRK-2 acts on the D2-like dopamine receptor DOP-3 to inhibit Go signaling and positively modulate NCA-1 and NCA-2 activity.
Title: Dopamine negatively modulates the NCA ion channels in C. elegans.
These results demonstrate that GRK-2 modulates 5-HT metabolism by regulating AMX-2 function and that 5-HIAA may function in the SER-1 signaling pathway.
Title: G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.
We have demonstrated functional roles for broadly conserved GRK2/3 structural domains in the in vivo regulation of organismal behavior.
Title: Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W02B3.2 (e-PCR)
- UniSTS:311086

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dopamine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to salt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in serotonin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G protein-coupled receptor kinase 2

NP_497235.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

676122..680658

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064834.6 → NP_497235.2 G protein-coupled receptor kinase 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497235.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09639

Conserved Domains (5) summary

cd08747
Location:30 → 186

RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)

smart00133
Location:456 → 530

S_TK_X; Extension to Ser/Thr-type protein kinases

cd01240
Location:553 → 676

PH_GRK2_subgroup; G Protein-Coupled Receptor Kinase 2 subgroup pleckstrin homology (PH) domain

cd05606
Location:196 → 475

STKc_beta_ARK; Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase

pfam00069
Location:191 → 455

Pkinase; Protein kinase domain