U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    nrf-6 Nose resistant to fluoxetine protein 6 [ Caenorhabditis elegans ]

    Gene ID: 174287, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nrf-6
    Official Full Name
    Nose resistant to fluoxetine protein 6
    Primary source
    WormBase:WBGene00003813
    Locus tag
    CELE_C08B11.4
    See related
    AllianceGenome:WB:WBGene00003813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups and lipid binding activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Is expressed in hyp3; hyp5; and intestine. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nrf-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    13
    Sequence:
    Chromosome: II; NC_003280.10 (8028953..8032708, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ARID domain-containing protein;SWI/SNF nucleosome remodeling complex component Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Splicing factor 3B subunit 4 Neighboring gene Actin-like protein C08B11.6 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. How do antidepressants work? Prospects for genetic analysis of drug mechanisms. Schafer WR. Cell, 1999 Sep 3. PMID 10490094
    2. Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans. Brejning J, et al. Aging Cell, 2014 Feb. PMID 24286221, Free PMC Article
    3. Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins. Choy RK, et al. Mol Cell, 1999 Aug. PMID 10488330
    4. Dietary manipulation implicates lipid signaling in the regulation of germ cell maintenance in C. elegans. Watts JL, et al. Dev Biol, 2006 Apr 15. PMID 16487504, Free PMC Article
    5. Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development. Suzuki Y, et al. Genes Dev, 2006 Feb 15. PMID 16481471, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nrf-6 is required in the intestine for sensitivity to fluoxetine-induced nose contraction.
      Title: Fluoxetine-resistance genes in Caenorhabditis elegans function in the intestine and may act in drug transport.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Nose resistant to fluoxetine protein 6
    NP_495680.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8028953..8032708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063279.6 → NP_495680.1  Nose resistant to fluoxetine protein 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495680.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09225, Q9U4I8
      Conserved Domains (3) summary
      smart00703
      Location:151 → 288
      NRF; N-terminal domain in C. elegans NRF-6 (Nose Resistant to Fluoxetine-4) and NDG-4 (resistant to nordihydroguaiaretic acid-4)
      COG1835
      Location:375 → 790
      OafA; Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains [Cell wall/membrane/envelope biogenesis]
      pfam01757
      Location:375 → 777
      Acyl_transf_3; Acyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09225.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools