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    cbl-1 cystathionine gamma-lyase [ Caenorhabditis elegans ]

    Gene ID: 172759, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cbl-1
    Official Full Name
    cystathionine gamma-lyase
    Primary source
    WormBase:WBGene00007533
    Locus tag
    CELE_C12C8.2
    See related
    AllianceGenome:WB:WBGene00007533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carbon-sulfur lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in transsulfuration. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cbl-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (9327857..9330928)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans. Phan HD, et al. Metabolomics, 2023 Jun 8. PMID 37289273
    2. Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response. Watson E, et al. Cell, 2013 Mar 28. PMID 23540702, Free PMC Article
    3. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
    4. Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Xia Q, et al. Redox Biol, 2023 Apr. PMID 36791646, Free PMC Article
    5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables L-cysteine desulfhydrase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-cystine L-cysteine-lyase (deaminating) IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbon-sulfur lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine gamma-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transsulfuration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cystathionine gamma-lyase
    NP_001122419.1
    • Partially confirmed by transcript evidence
    NP_492486.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9327857..9330928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060085.4 → NP_492486.2  cystathionine gamma-lyase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492486.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02215
      Conserved Domains (2) summary
      PRK09028
      Location:85 → 450
      PRK09028; cystathionine beta-lyase; Provisional
      pfam01053
      Location:69 → 449
      Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme

    2. NM_001128947.4 → NP_001122419.1  cystathionine gamma-lyase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122419.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JYW2
      Conserved Domains (1) summary
      cl18945
      Location:69 → 170
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    Nucleotide Protein
    Heading Accession and Version

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