che-3 Cytoplasmic dynein 2 heavy chain 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: che-3
Official Full Name: Cytoplasmic dynein 2 heavy chain 1
Primary source: WormBase:WBGene00000485
Locus tag: CELE_F18C12.1
See related: AllianceGenome:WB:WBGene00000485
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in several processes, including dauer entry; non-motile cilium assembly; and positive regulation of dauer larval development. Located in non-motile cilium. Is expressed in I4 neuron; ciliated neurons; and nerve ring. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy and asphyxiating thoracic dystrophy 3. Orthologous to human DYNC2H1 (dynein cytoplasmic 2 heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See che-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 48

Sequence:: Chromosome: I; NC_003279.8 (8062007..8081671, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wild-type worms are induced to display an L1 (first larval stage) surface epitope at later larval stages when grown on an extract of spent culture medium; this was abolished in chemotaxis-defective che-3 mutants.
Title: Chemosensory control of surface antigen switching in the nematode Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F18C12.1 (e-PCR)
- UniSTS:309825

STS1-120 (e-PCR)
- UniSTS:241605

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intraciliary retrograde transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in 9+2 motile cilium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynein complex	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cytoplasmic dynein 2 heavy chain 1

NP_492221.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8062007..8081671 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059820.4 → NP_492221.2 Cytoplasmic dynein 2 heavy chain 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492221.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19542

Conserved Domains (6) summary

pfam03028
Location:3502 → 4161

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08385
Location:234 → 634

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1086 → 1480

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:2790 → 3124

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:3148 → 3361

AAA_9; ATP-binding dynein motor region D5

cl21455
Location:1599 → 1829

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases