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    uad-2 Chromo domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172354, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uad-2
    Official Full Name
    Chromo domain-containing protein
    Primary source
    WormBase:WBGene00019429
    Locus tag
    CELE_K06A5.1
    See related
    AllianceGenome:WB:WBGene00019429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables H3K27me3 modified histone binding activity. Involved in positive regulation of piRNA transcription. Located in chromatin and nuclear inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See uad-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (6473207..6476756)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene DUF389 domain membrane protein Neighboring gene M-phase inducer phosphatase cdc-25.1 Neighboring gene CTLH domain-containing protein;WD_REPEATS_REGION domain-containing protein Neighboring gene STAS domain-containing protein Neighboring gene ncRNA Neighboring gene Lariat debranching enzyme Neighboring gene Mediator of RNA polymerase II transcription subunit 18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A chromodomain protein mediates heterochromatin-directed piRNA expression. Huang X, et al. Proc Natl Acad Sci U S A, 2021 Jul 6. PMID 34187893, Free PMC Article
    2. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables H3K27me3 modified histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of piRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chromo domain-containing protein
    NP_001300423.1
    • Confirmed by transcript evidence
    NP_001300424.1
    • Confirmed by transcript evidence
    NP_001379834.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6473207..6476756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001313494.3 → NP_001300423.1  Chromo domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AR81
      Conserved Domains (1) summary
      cd00024
      Location:60 → 105
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    2. NM_001392447.1 → NP_001379834.1  Chromo domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44553

    3. NM_001313495.3 → NP_001300424.1  Chromo domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ATN5
    Nucleotide Protein
    Heading Accession and Version

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