edc-4 FHA domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: edc-4
Official Full Name: FHA domain-containing protein
Primary source: WormBase:WBGene00021551
Locus tag: CELE_Y44E3A.6
See related: AllianceGenome:WB:WBGene00021551
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Predicted to be located in cytoplasm. Predicted to be active in P-body. Orthologous to human EDC4 (enhancer of mRNA decapping 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See edc-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 12

Sequence:: Chromosome: I; NC_003279.8 (3340212..3349914, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization.
Title: EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y44E3A.6 (e-PCR)
- UniSTS:318872

W05F2.1 (e-PCR)
- UniSTS:319713

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in deadenylation-independent decapping of nuclear-transcribed mRNA	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FHA domain-containing protein

NP_001391101.1

Confirmed by transcript evidence

NP_001391102.1

Confirmed by transcript evidence

NP_740827.1

Confirmed by transcript evidence

NP_740828.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3340212..3349914 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170842.7 → NP_740827.1 FHA domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740827.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8ITV7

Conserved Domains (1) summary

pfam16529
Location:52 → 377

Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
NM_001404253.1 → NP_001391102.1 FHA domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QCB9
NM_171835.7 → NP_740828.1 FHA domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740828.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8ITV6

Conserved Domains (1) summary

pfam16529
Location:52 → 377

Ge1_WD40; WD40 region of Ge1, enhancer of mRNA-decapping protein
NM_001404249.1 → NP_001391101.1 FHA domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QBN9