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    Gpc2 glypican 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpc2provided by RGD
    Official Full Name
    glypican 2provided by RGD
    Primary source
    RGD:621363
    See related
    EnsemblRapid:ENSRNOG00000001367 AllianceGenome:RGD:621363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in neuron differentiation; positive regulation of neuron projection development; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface and synapse. Orthologous to human GPC2 (glypican 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 12.2), Testes (RPKM 12.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpc2 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22391489..22397822, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17277875..17284297, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19593041..19599374, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 14 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene STAG3 cohesin complex component Neighboring gene uncharacterized LOC134481272 Neighboring gene PVR related immunoglobulin domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix. Paveliev M, et al. Sci Rep, 2016 Sep 27. PMID 27671118, Free PMC Article
    2. Cerebroglycan: an integral membrane heparan sulfate proteoglycan that is unique to the developing nervous system and expressed specifically during neuronal differentiation. Stipp CS, et al. J Cell Biol, 1994 Jan. PMID 8294498, Free PMC Article
    3. Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth. Kurosawa N, et al. Glycoconj J, 2001 Jun. PMID 12084985
    4. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Williams EH, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20231458, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glypican-2
    Names
    HSPG M13
    cerebroglycan

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138511.2 → NP_612520.1  glypican-2 precursor

      See identical proteins and their annotated locations for NP_612520.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P51653
      UniProtKB/TrEMBL
      A6KSU5, A6KSU6
      Related
      ENSRNOP00000001849.2, ENSRNOT00000001849.6
      Conserved Domains (1) summary
      pfam01153
      Location:22 → 565
      Glypican; Glypican

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      22391489..22397822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089053.2 → XP_038944981.1  glypican-2 isoform X2

      Conserved Domains (1) summary
      pfam01153
      Location:1 → 320
      Glypican

    2. XM_039089052.2 → XP_038944980.1  glypican-2 isoform X2

      Conserved Domains (1) summary
      pfam01153
      Location:1 → 320
      Glypican

    3. XM_039089054.2 → XP_038944982.1  glypican-2 isoform X2

      Conserved Domains (1) summary
      pfam01153
      Location:1 → 320
      Glypican

    4. XM_039089051.2 → XP_038944979.1  glypican-2 isoform X1

      Conserved Domains (1) summary
      pfam01153
      Location:22 → 437
      Glypican
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51653.1 GenPept UniProtKB/Swiss-Prot:P51653

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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