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    Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170919, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Agpat4provided by RGD
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 4provided by RGD
    Primary source
    RGD:619916
    See related
    EnsemblRapid:ENSRNOG00000017731 AllianceGenome:RGD:619916
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phospholipid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system and mitochondrial outer membrane. Orthologous to human AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 133.0), Adrenal (RPKM 98.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Agpat4 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (51075081..51181548, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (48525131..48633798, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48716094..48826292, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099124 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene mitogen activated protein kinase kinase kinase 4 Neighboring gene uncharacterized LOC108349099 Neighboring gene uncharacterized LOC134482716 Neighboring gene uncharacterized LOC134482715 Neighboring gene parkin RBR E3 ubiquitin protein ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. Eto M, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333445
    2. Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. Bradley RM, et al. Biochim Biophys Acta, 2015 Dec. PMID 26417903
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93227

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase delta
    Names
    1-AGP acyltransferase 4
    1-AGPAT 4
    1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, delta)
    1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
    LPAAT-delta
    lysophosphatidic acid acyltransferase delta
    NP_596897.1
    XP_006227918.1
    XP_006227919.1
    XP_063128906.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133406.2 → NP_596897.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta

      See identical proteins and their annotated locations for NP_596897.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q924S1
      UniProtKB/TrEMBL
      A0A8I6ALQ9, A6KJY8
      Related
      ENSRNOP00000024213.2, ENSRNOT00000024213.6
      Conserved Domains (1) summary
      PLN02380
      Location:20 → 326
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      51075081..51181548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006227857.5 → XP_006227919.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

      See identical proteins and their annotated locations for XP_006227919.1

      UniProtKB/Swiss-Prot
      Q924S1
      UniProtKB/TrEMBL
      A0A8I6ALQ9, A6KJY8
      Conserved Domains (1) summary
      PLN02380
      Location:20 → 326
      PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

    2. XM_006227856.5 → XP_006227918.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWH4, A0A8I6ALQ9
      Related
      ENSRNOP00000069883.1, ENSRNOT00000082958.3
      Conserved Domains (3) summary
      cd07990
      Location:98 → 292
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      COG0204
      Location:51 → 325
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      pfam16076
      Location:279 → 350
      Acyltransf_C; Acyltransferase C-terminus

    3. XM_063272836.1 → XP_063128906.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924S1.1 GenPept UniProtKB/Swiss-Prot:Q924S1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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