s1pr2 sphingosine-1-phosphate receptor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: s1pr2provided by ZNC
Official Full Name: sphingosine-1-phosphate receptor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-020123-2
See related: Ensembl:ENSDARG00000036548 AllianceGenome:ZFIN:ZDB-GENE-020123-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mil; edg5; s1p2
Summary: Predicted to enable sphingosine-1-phosphate receptor activity. Acts upstream of or within several processes, including embryonic morphogenesis; inner ear development; and neuromast hair cell development. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including cardiovascular system; midbrain hindbrain boundary neural rod; midbrain hindbrain boundary neural tube; nervous system; and pleuroperitoneal region. Used to study carcinoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (54616015..54669185, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (54361413..54414583, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In embryos defective for S1pr2/Galpha13 signaling, endocardial precursors failed to migrate towards the midline, and the presumptive endocardium surrounded the bilaterally-located myocardial cells rather than being encompassed by them.
Title: S1pr2/Gα13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence.
beta-arrestin 2 and GRK2 colocalize with S1p2 in developing zebrafish embryos and depletion of GRK2 in the S1p2 R150H miles apart zebrafish partially rescued cardia bifida.
Title: Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.
Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning
Title: Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.
S1pr2/Galpha13 signaling controls myocardial migration by regulating endoderm convergence.
Title: S1pr2/Gα13 signaling controls myocardial migration by regulating endoderm convergence.
S1P(2) loss in a zebrafish mutant disrupted epithelial cell extrusion.
Title: Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway.
mil encodes Edg5, a sphingosine-1-phosphate receptor.
Title: Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables sphingosine-1-phosphate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior lateral line neuromast hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardioblast migration to the midline involved in heart rudiment formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cardioblast migration to the midline involved in heart rudiment formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell migration to the midline involved in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart rudiment formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart rudiment formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesodermal cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otolith development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within semicircular canal development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sphingosine-1-phosphate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sphingosine 1-phosphate receptor 2

Names: S1P receptor 2; S1P receptor Edg-5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5; miles apart; sphingosine 1-phosphate receptor Edg-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.