Lama2 laminin, alpha 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lama2provided by MGI
Official Full Name: laminin, alpha 2provided by MGI
Primary source: MGI:MGI:99912
See related: Ensembl:ENSMUSG00000019899 AllianceGenome:MGI:99912
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: dy; mer; merosin; mKIAA4087; 5830440B04
Summary: Predicted to be an extracellular matrix structural constituent. Acts upstream of or within axon guidance and positive regulation of cholinergic synaptic transmission. Located in basement membrane and sarcolemma. Is active in neuromuscular junction and synaptic cleft. Is expressed in several structures, including alimentary system; extracellular matrix; metanephros; musculature; and nervous system. Used to study congenital merosin-deficient muscular dystrophy 1A. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to human LAMA2 (laminin subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 7.3), heart adult (RPKM 7.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 14.23 cM

Exon count:: 66

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (26857281..27493021, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (26981285..27617191, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dual transgene amelioration of Lama2-null muscular dystrophy.
Title: Dual transgene amelioration of Lama2-null muscular dystrophy.
PDGFRbeta-positive cell-mediated post-stroke remodeling of fibronectin and laminin alpha2 for tissue repair and functional recovery.
Title: PDGFRβ-positive cell-mediated post-stroke remodeling of fibronectin and laminin α2 for tissue repair and functional recovery.
Laminin-111 protein therapy after disease onset slows muscle disease in a mouse model of laminin-alpha2 related congenital muscular dystrophy.
Title: Laminin-111 protein therapy after disease onset slows muscle disease in a mouse model of laminin-α2 related congenital muscular dystrophy.
Organisation of extracellular matrix proteins laminin and agrin in pericapillary basal laminae in mouse brain.
Title: Organisation of extracellular matrix proteins laminin and agrin in pericapillary basal laminae in mouse brain.
Laminin alpha2, alpha4, and alpha5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells.
Title: Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells.
we identified LAMA2 as the coreceptor for staphylococcal superantigens
Title: Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells.
Here, we demonstrate that the triceps muscles of the dy2j/dy2j mouse model of LAMA2-CMD demonstrate very mild myopathic findings compared with the tibialis anterior (TA) muscles that undergo severe atrophy and fibrosis, suggesting a protective mechanism in the upper limbs of these mice
Title: Increased polyamines as protective disease modifiers in congenital muscular dystrophy.
These findings provide a mechanistic understanding of LAMA2 muscular dystrophy and establish a strong basis for a potential treatment.
Title: Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
Title: Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination.
Deletion of integrin alpha7 subunit does not aggravate the phenotype of laminin alpha2 chain-deficient mice. laminin-211 and integrin alpha7beta1 have intersecting roles in skeletal muscle.
Title: Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Spontaneous (5) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MT905 (e-PCR)
- UniSTS:126023

D10Mit126.1 (e-PCR), detects polymorphism
- UniSTS:126024

03.MMHAP11FLA3.seq (e-PCR)
- UniSTS:122727

Lama2 (e-PCR), detects polymorphism
- UniSTS:143748

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Schwann cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of muscle cell differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of basement membrane organization	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	NAS Non-traceable Author Statement more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
part_of protein complex involved in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: laminin subunit alpha-2

Names: dystrophia muscularis; laminin M chain; laminin-12 subunit alpha; laminin-2 subunit alpha; laminin-4 subunit alpha; merosin heavy chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008481.3 → NP_032507.2 laminin subunit alpha-2 precursor

See identical proteins and their annotated locations for NP_032507.2

Status: VALIDATED

Source sequence(s)

AC101709, AC152982, AC153800, AC155942, AC167232, AC171406

Consensus CDS

CCDS48526.1

UniProtKB/Swiss-Prot

F8VQ43, Q05003, Q60675, Q64061

Related

ENSMUSP00000090304.6, ENSMUST00000092639.12

Conserved Domains (12) summary

smart00180
Location:963 → 1007

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1225 → 1360

LamB; Laminin B domain

cd00055
Location:913 → 960

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2937 → 3089

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00052
Location:579 → 707

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1056 → 1104

Laminin_EGF; Laminin EGF domain

pfam00054
Location:2789 → 2917

Laminin_G_1; Laminin G domain

pfam00055
Location:45 → 281

Laminin_N; Laminin N-terminal (Domain VI)

pfam01442
Location:1845 → 2059

Apolipoprotein; Apolipoprotein A1/A4/E domain

pfam06008
Location:1584 → 1848

Laminin_I; Laminin Domain I

pfam06009
Location:2033 → 2168

Laminin_II; Laminin Domain II

cl02488
Location:1682 → 1881

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

26857281..27493021 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313815.1 → XP_017169304.1 laminin subunit alpha-2 isoform X3

Conserved Domains (11) summary

smart00180
Location:963 → 1007

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1225 → 1360

LamB; Laminin B domain

COG1196
Location:1697 → 2010

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00055
Location:913 → 960

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2931 → 3083

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam06008
Location:1589 → 1848

Laminin_I; Laminin Domain I

pfam00054
Location:2783 → 2911

Laminin_G_1; Laminin G domain

pfam00052
Location:579 → 718

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1056 → 1104

Laminin_EGF; Laminin EGF domain

pfam00055
Location:45 → 281

Laminin_N; Laminin N-terminal (Domain VI)

pfam06009
Location:2033 → 2166

Laminin_II; Laminin Domain II
XM_011243134.1 → XP_011241436.1 laminin subunit alpha-2 isoform X1

Conserved Domains (11) summary

smart00180
Location:963 → 1007

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1225 → 1360

LamB; Laminin B domain

COG1196
Location:1697 → 2010

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00055
Location:913 → 960

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2935 → 3087

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam06008
Location:1589 → 1848

Laminin_I; Laminin Domain I

pfam00054
Location:2787 → 2915

Laminin_G_1; Laminin G domain

pfam00052
Location:579 → 718

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1056 → 1104

Laminin_EGF; Laminin EGF domain

pfam00055
Location:45 → 281

Laminin_N; Laminin N-terminal (Domain VI)

pfam06009
Location:2033 → 2166

Laminin_II; Laminin Domain II
XM_011243135.1 → XP_011241437.1 laminin subunit alpha-2 isoform X2

Conserved Domains (11) summary

smart00180
Location:963 → 1007

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1225 → 1360

LamB; Laminin B domain

COG1196
Location:1697 → 2010

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00055
Location:913 → 960

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:2933 → 3085

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam06008
Location:1589 → 1848

Laminin_I; Laminin Domain I

pfam00054
Location:2785 → 2913

Laminin_G_1; Laminin G domain

pfam00052
Location:579 → 718

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1056 → 1104

Laminin_EGF; Laminin EGF domain

pfam00055
Location:45 → 281

Laminin_N; Laminin N-terminal (Domain VI)

pfam06009
Location:2033 → 2168

Laminin_II; Laminin Domain II
XM_006512566.5 → XP_006512629.1 laminin subunit alpha-2 isoform X4

Conserved Domains (8) summary

smart00180
Location:963 → 1007

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1225 → 1360

LamB; Laminin B domain

cd00055
Location:913 → 960

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

TIGR02169
Location:1758 → 1951

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam06008
Location:1589 → 1848

Laminin_I; Laminin Domain I

pfam00052
Location:579 → 718

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1056 → 1104

Laminin_EGF; Laminin EGF domain

pfam00055
Location:45 → 281

Laminin_N; Laminin N-terminal (Domain VI)