Kif12 kinesin family member 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif12provided by MGI
Official Full Name: kinesin family member 12provided by MGI
Primary source: MGI:MGI:1098232
See related: Ensembl:ENSMUSG00000028357 AllianceGenome:MGI:1098232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Located in microtubule organizing center. Is expressed in embryo and inner cell mass. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human KIF12 (kinesin family member 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in kidney adult (RPKM 61.1), colon adult (RPKM 9.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 33.96 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (63076185..63090382, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (63157948..63172145, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kif12 is a candidate gene within the major polycystic kidney disease modifier 2 locus that modulates renal cystic disease severity in the Cys1cpk mouse.
Title: Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse.
the microtubule motor KIF12 mediates an antioxidant cascade in beta cells as an intracellular target of excess fat intake or "lipotoxicity."
Title: Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells.
HNF-1beta regulates transcription of the PKD modifier gene Kif12.
Title: HNF-1beta regulates transcription of the PKD modifier gene Kif12.
Positional candidate gene, Kif12, fulfills the major criteria for quantitative trait loci gene discovery established by the Complex Trait Consortium, and, thus, it is proposed that Kif12 is a cpk modifier gene.
Title: Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF12

Names: N-9 kinesin; kinesin 12; kinesin superfamily protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001317352.1 → NP_001304281.1 kinesin-like protein KIF12 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL691496

Consensus CDS

CCDS89761.1

UniProtKB/TrEMBL

A0A097ZP89, A0A1Y7VK29

Related

ENSMUSP00000152690.2, ENSMUST00000156618.9

Conserved Domains (3) summary

cd00106
Location:25 → 358

KISc; Kinesin motor domain

pfam00225
Location:31 → 360

Kinesin; Kinesin motor domain

pfam12711
Location:379 → 464

Kinesin-relat_1; Kinesin motor
NM_010616.3 → NP_034746.1 kinesin-like protein KIF12 isoform 2

See identical proteins and their annotated locations for NP_034746.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AK018598, BP765257

Consensus CDS

CCDS18249.1

UniProtKB/Swiss-Prot

O35061, Q9D2Z8

UniProtKB/TrEMBL

A0A097ZP89

Related

ENSMUSP00000030042.3, ENSMUST00000030042.3

Conserved Domains (3) summary

cd00106
Location:25 → 358

KISc; Kinesin motor domain

pfam00225
Location:31 → 360

Kinesin; Kinesin motor domain

pfam12711
Location:379 → 464

Kinesin-relat_1; Kinesin motor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

63076185..63090382 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319998.3 → XP_017175487.1 kinesin-like protein KIF12 isoform X1

UniProtKB/TrEMBL

A0A097ZP89

Conserved Domains (1) summary

cd00106
Location:25 → 358

KISc; Kinesin motor domain
XM_017319999.3 → XP_017175488.1 kinesin-like protein KIF12 isoform X2

UniProtKB/TrEMBL

A0A097ZP89

Conserved Domains (1) summary

cd00106
Location:25 → 358

KISc; Kinesin motor domain
XM_017320000.2 → XP_017175489.1 kinesin-like protein KIF12 isoform X3

Conserved Domains (1) summary

cd00106
Location:25 → 358

KISc; Kinesin motor domain