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    Il3ra interleukin 3 receptor, alpha chain [ Mus musculus (house mouse) ]

    Gene ID: 16188, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Il3raprovided by MGI
    Official Full Name
    interleukin 3 receptor, alpha chainprovided by MGI
    Primary source
    MGI:MGI:96553
    See related
    Ensembl:ENSMUSG00000068758 AllianceGenome:MGI:96553
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD123; SUT-1; CDw123
    Summary
    Predicted to enable interleukin-3 receptor activity. Acts upstream of or within interleukin-3-mediated signaling pathway. Predicted to be located in endomembrane system and plasma membrane. Is expressed in several structures, including bone marrow; cardiovascular system mesenchyme; dorsal aorta; early conceptus; and umbilical or vitelline vessel. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 13.7), testis adult (RPKM 11.5) and 26 other tissues See more
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    Genomic context

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    See Il3ra in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (8114270..8123851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (14345912..14355493)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily T member 35 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5422 Neighboring gene olfactory receptor family 2 subfamily T member 1 Neighboring gene STARR-seq mESC enhancer starr_35990 Neighboring gene STARR-seq mESC enhancer starr_35989 Neighboring gene predicted gene 3895

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interleukin-3Ralpha+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3. Baumeister T, et al. J Invest Dermatol, 2003 Aug. PMID 12880419
    2. Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. Hara T, et al. Blood, 1995 May 1. PMID 7727767
    3. Genetic basis of hypo-responsiveness of A/J mice to interleukin-3. Leslie KB, et al. Blood, 1996 Apr 15. PMID 8605333
    4. Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. Ichihara M, et al. EMBO J, 1995 Mar 1. PMID 7889941, Free PMC Article
    5. IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells. Ullrich KA, et al. Gut, 2023 Nov. PMID 37541770, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia.
      Title: EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia.
    2. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Ralpha.
      Title: MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
    3. High IL3RA expression is associated with breast cancer.
      Title: IL-3R-alpha blockade inhibits tumor endothelial cell-derived extracellular vesicle (EV)-mediated vessel formation by targeting the β-catenin pathway.
    4. expression of the interleukin 3 receptor alpha (Il3ra also known as Cd123) subunit is dependent on Jmjd2/Kdm4 through a mechanism involving removal of H3K9me3 from the promoter of the Il3ra gene.
      Title: Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.
    5. Data indicate that the proliferative and differentiative effect of saponins from Sanguisorba officinalis (DYS) on megakaryocyte progenitor cells is correlated to the up-regulation of IL-3 receptor and c-kit expression.
      Title: [Effect of total saponins from Sanguisorba officinalis on megakaryocyte progenitor cells proliferation, differentiation and relative receptor expression].
    6. Findings indicate that SLP-76 is an essential signaling component for basophil activation downstream of both FcepsilonRI and the IL-3 receptor.
      Title: SLP-76 is required for high-affinity IgE receptor- and IL-3 receptor-mediated activation of basophils.
    7. Interleukin-3/dendritic cells expressed higher levels of interleukin-3 receptor.
      Title: Interleukin-3Ralpha+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-3 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to interleukin-3 IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within interleukin-3-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in interleukin-3-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-3-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-3 receptor subunit alpha
    Names
    IL-3 receptor alpha chain
    IL-3 receptor subunit alpha
    IL-3R subunit alpha
    IL-3R-alpha
    IL-3RA
    Il-3 alpha subunit
    interleukin-3 receptor class II alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418423.1 → NP_001405352.1  interleukin-3 receptor subunit alpha isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    2. NM_001418424.1 → NP_001405353.1  interleukin-3 receptor subunit alpha isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    3. NM_001418425.1 → NP_001405354.1  interleukin-3 receptor subunit alpha isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    4. NM_001418427.1 → NP_001405356.1  interleukin-3 receptor subunit alpha isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    5. NM_001418428.1 → NP_001405357.1  interleukin-3 receptor subunit alpha isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    6. NM_001418429.1 → NP_001405358.1  interleukin-3 receptor subunit alpha isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    7. NM_001418436.1 → NP_001405365.1  interleukin-3 receptor subunit alpha isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689
      UniProtKB/Swiss-Prot
      B9VI80, P26952

    8. NM_001418437.1 → NP_001405366.1  interleukin-3 receptor subunit alpha isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689
      UniProtKB/Swiss-Prot
      B9VI80, P26952
      Related
      ENSMUSP00000153358.2, ENSMUST00000224163.2

    9. NM_001418440.1 → NP_001405369.1  interleukin-3 receptor subunit alpha isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    10. NM_001418442.1 → NP_001405371.1  interleukin-3 receptor subunit alpha isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    11. NM_001418443.1 → NP_001405372.1  interleukin-3 receptor subunit alpha isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    12. NM_001418445.1 → NP_001405374.1  interleukin-3 receptor subunit alpha isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    13. NM_001418447.1 → NP_001405376.1  interleukin-3 receptor subunit alpha isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    14. NM_001418449.1 → NP_001405378.1  interleukin-3 receptor subunit alpha isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    15. NM_001418450.1 → NP_001405379.1  interleukin-3 receptor subunit alpha isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    16. NM_001418451.1 → NP_001405380.1  interleukin-3 receptor subunit alpha isoform 7 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    17. NM_001418452.1 → NP_001405381.1  interleukin-3 receptor subunit alpha isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689
      Related
      ENSMUSP00000153086.2, ENSMUST00000224877.2

    18. NM_001418453.1 → NP_001405382.1  interleukin-3 receptor subunit alpha isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    19. NM_001418454.1 → NP_001405383.1  interleukin-3 receptor subunit alpha isoform 8 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    20. NM_001418455.1 → NP_001405384.1  interleukin-3 receptor subunit alpha isoform 9

      Status: VALIDATED

      Source sequence(s)
      CT025689

    21. NM_001418456.1 → NP_001405385.1  interleukin-3 receptor subunit alpha isoform 9

      Status: VALIDATED

      Source sequence(s)
      CT025689

    22. NM_001418457.1 → NP_001405386.1  interleukin-3 receptor subunit alpha isoform 9

      Status: VALIDATED

      Source sequence(s)
      CT025689

    23. NM_001418458.1 → NP_001405387.1  interleukin-3 receptor subunit alpha isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    24. NM_001418459.1 → NP_001405388.1  interleukin-3 receptor subunit alpha isoform 10 precursor

      Status: VALIDATED

      Source sequence(s)
      CT025689

    25. NM_001418460.1 → NP_001405389.1  interleukin-3 receptor subunit alpha isoform 11

      Status: VALIDATED

      Source sequence(s)
      CT025689

    26. NM_001418461.1 → NP_001405390.1  interleukin-3 receptor subunit alpha isoform 11

      Status: VALIDATED

      Source sequence(s)
      CT025689

    27. NM_001418462.1 → NP_001405391.1  interleukin-3 receptor subunit alpha isoform 12

      Status: VALIDATED

      Source sequence(s)
      CT025689

    28. NM_008369.2 → NP_032395.1  interleukin-3 receptor subunit alpha isoform 3 precursor

      See identical proteins and their annotated locations for NP_032395.1

      Status: VALIDATED

      Source sequence(s)
      CT025689
      Consensus CDS
      CCDS26827.1
      UniProtKB/Swiss-Prot
      B9VI80, P26952
      Related
      ENSMUSP00000088079.3, ENSMUST00000090591.4
      Conserved Domains (1) summary
      pfam09240
      Location:120 → 233
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      8114270..8123851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247655.1 → XP_030103515.1  interleukin-3 receptor subunit alpha isoform X15

      Conserved Domains (1) summary
      pfam09240
      Location:113 → 223
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    2. XM_017315868.1 → XP_017171357.1  interleukin-3 receptor subunit alpha isoform X18

      Conserved Domains (2) summary
      pfam18611
      Location:149 → 209
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
      cl21522
      Location:237 → 272
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_017315866.1 → XP_017171355.1  interleukin-3 receptor subunit alpha isoform X11

      Conserved Domains (2) summary
      pfam18611
      Location:149 → 209
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain
      cl21522
      Location:237 → 272
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. XM_036158476.1 → XP_036014369.1  interleukin-3 receptor subunit alpha isoform X10

      Conserved Domains (1) summary
      cl21522
      Location:237 → 272
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. XM_017315865.3 → XP_017171354.1  interleukin-3 receptor subunit alpha isoform X9

      Conserved Domains (2) summary
      pfam09240
      Location:237 → 347
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:149 → 209
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

    6. XM_017315864.3 → XP_017171353.1  interleukin-3 receptor subunit alpha isoform X7

      Conserved Domains (2) summary
      pfam09240
      Location:237 → 347
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:149 → 209
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

    7. XM_036158475.1 → XP_036014368.1  interleukin-3 receptor subunit alpha isoform X5

      Conserved Domains (1) summary
      pfam09240
      Location:237 → 347
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    8. XM_017315867.3 → XP_017171356.1  interleukin-3 receptor subunit alpha isoform X16

      Conserved Domains (2) summary
      pfam09240
      Location:237 → 347
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:149 → 209
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

    9. XM_036158477.1 → XP_036014370.1  interleukin-3 receptor subunit alpha isoform X13

      Conserved Domains (1) summary
      pfam09240
      Location:170 → 280
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    10. XM_036158478.1 → XP_036014371.1  interleukin-3 receptor subunit alpha isoform X19

      Conserved Domains (1) summary
      cl21522
      Location:113 → 148
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    11. XM_006517946.3 → XP_006518009.1  interleukin-3 receptor subunit alpha isoform X21

      Conserved Domains (1) summary
      cl21522
      Location:8 → 85
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    12. XM_036158479.1 → XP_036014372.1  interleukin-3 receptor subunit alpha isoform X20

    13. XM_030247656.1 → XP_030103516.1  interleukin-3 receptor subunit alpha isoform X17

      Conserved Domains (1) summary
      pfam09240
      Location:108 → 218
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    14. XM_006517940.2 → XP_006518003.1  interleukin-3 receptor subunit alpha isoform X12

      Conserved Domains (2) summary
      pfam09240
      Location:119 → 229
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
      pfam18611
      Location:31 → 91
      IL3Ra_N; IL-3 receptor alpha chain N-terminal domain

    15. XM_006517942.4 → XP_006518005.1  interleukin-3 receptor subunit alpha isoform X15

      See identical proteins and their annotated locations for XP_006518005.1

      Conserved Domains (1) summary
      pfam09240
      Location:113 → 223
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26952.1 GenPept UniProtKB/Swiss-Prot:P26952

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