Il18r1 interleukin 18 receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il18r1provided by MGI
Official Full Name: interleukin 18 receptor 1provided by MGI
Primary source: MGI:MGI:105383
See related: Ensembl:ENSMUSG00000026070 AllianceGenome:MGI:105383
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il1rrp; Il18ralpha
Summary: Enables interleukin-18 receptor activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including T-helper 1 cell differentiation; interleukin-18-mediated signaling pathway; and positive regulation of type II interferon production. Predicted to be part of interleukin-18 receptor complex. Predicted to be active in cell surface and plasma membrane. Is expressed in aorta-gonad-mesonephros and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL18R1 (interleukin 18 receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 4.7), bladder adult (RPKM 0.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 19.27 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (40504712..40540014)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (40465552..40500854)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL18 Receptor Signaling Inhibits Intratumoral CD8[+] T-Cell Migration in a Murine Pancreatic Cancer Model.
Title: IL18 Receptor Signaling Inhibits Intratumoral CD8(+) T-Cell Migration in a Murine Pancreatic Cancer Model.
Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.
Title: Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.
The Basophil IL-18 Receptor Precisely Regulates the Host Immune Response and Malaria-Induced Intestinal Permeability and Alters Parasite Transmission to Mosquitoes without Effect on Gametocytemia.
Title: The Basophil IL-18 Receptor Precisely Regulates the Host Immune Response and Malaria-Induced Intestinal Permeability and Alters Parasite Transmission to Mosquitoes without Effect on Gametocytemia.
IL-18/IL-18R Signaling Is Dispensable for ILC Development But Constrains the Growth of ILCP/ILCs.
Title: IL-18/IL-18R Signaling Is Dispensable for ILC Development But Constrains the Growth of ILCP/ILCs.
IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock.
Title: IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock.
Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Ralpha(hi) CD8(+) T cells.
Title: Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rα(hi) CD8(+) T cells.
IL-18R signaling is required for gammadelta T cell response and confers resistance to Trypanosoma cruzi infection.
Title: IL-18R signaling is required for γδ T cell response and confers resistance to Trypanosoma cruzi infection.
Insights into the Role of Innate Immunity in Cervicovaginal Papillomavirus Infection from Studies Using Gene-Deficient Mice.
Title: Insights into the Role of Innate Immunity in Cervicovaginal Papillomavirus Infection from Studies Using Gene-Deficient Mice.
Inhibition of the IL-18 Receptor Signaling Pathway Ameliorates Disease in a Murine Model of Rheumatoid Arthritis.
Title: Inhibition of the IL-18 Receptor Signaling Pathway Ameliorates Disease in a Murine Model of Rheumatoid Arthritis.
asthma is very likely to be determined by balance of IL-18/IL-18BP/IL-18R expression in inflammatory cells.
Title: Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (2) 1 citation

General gene information

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Markers

Il18r1 (e-PCR), detects polymorphism
- UniSTS:525666

fl05f06.x1 (e-PCR)
- UniSTS:201902

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables interleukin-18 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-18 binding	ISS Inferred from Sequence or Structural Similarity more info
enables interleukin-18 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-18 receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables interleukin-18 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-18 receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T-helper 1 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adaptive immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-18-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-18-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-18-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within natural killer cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
part_of interleukin-18 receptor complex	IEA Inferred from Electronic Annotation more info
part_of interleukin-18 receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-18 receptor 1

Names: CD218 antigen-like family member A; IL-18R-1; IL-18R-alpha; IL-18R1; IL-18Ralpha; IL-1Rrp; IL1 receptor-related protein; IL1R-rp; interleukin 1 receptor related protein; interleukin-18 receptor alpha

NP_001155314.1

EC 3.2.2.6

NP_001155315.1

EC 3.2.2.6

NP_032391.1

EC 3.2.2.6

XP_006495790.1

EC 3.2.2.6

XP_006495791.1

EC 3.2.2.6

XP_006495792.1

EC 3.2.2.6

XP_006495793.1

EC 3.2.2.6

XP_006495795.1

EC 3.2.2.6

XP_006495797.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161842.1 → NP_001155314.1 interleukin-18 receptor 1 isoform b precursor

See identical proteins and their annotated locations for NP_001155314.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice pattern in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AC167126

Consensus CDS

CCDS48247.1

UniProtKB/TrEMBL

Q8C257

Related

ENSMUSP00000128277.2, ENSMUST00000167723.8

Conserved Domains (3) summary

cd00096
Location:46 → 113

Ig; Immunoglobulin domain

smart00410
Location:26 → 112

IG_like; Immunoglobulin like

cl11960
Location:131 → 205

Ig; Immunoglobulin domain
NM_001161843.1 → NP_001155315.1 interleukin-18 receptor 1 isoform b precursor

See identical proteins and their annotated locations for NP_001155315.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice pattern in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.

Source sequence(s)

AC167126

Consensus CDS

CCDS48247.1

UniProtKB/TrEMBL

Q8C257

Related

ENSMUSP00000141695.2, ENSMUST00000193391.6

Conserved Domains (3) summary

cd00096
Location:46 → 113

Ig; Immunoglobulin domain

smart00410
Location:26 → 112

IG_like; Immunoglobulin like

cl11960
Location:131 → 205

Ig; Immunoglobulin domain
NM_008365.2 → NP_032391.1 interleukin-18 receptor 1 isoform a precursor

See identical proteins and their annotated locations for NP_032391.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC167126

Consensus CDS

CCDS35549.1

UniProtKB/Swiss-Prot

Q61098

Related

ENSMUSP00000103679.3, ENSMUST00000108044.4

Conserved Domains (4) summary

PHA02785
Location:157 → 257

PHA02785; IL-beta-binding protein; Provisional

smart00410
Location:26 → 112

IG_like; Immunoglobulin like

pfam01582
Location:374 → 534

TIR; TIR domain

cl11960
Location:131 → 205

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

40504712..40540014

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495727.3 → XP_006495790.1 interleukin-18 receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006495790.1

UniProtKB/Swiss-Prot

Q61098

Conserved Domains (4) summary

PHA02785
Location:157 → 257

PHA02785; IL-beta-binding protein; Provisional

smart00410
Location:26 → 112

IG_like; Immunoglobulin like

pfam01582
Location:374 → 534

TIR; TIR domain

cl11960
Location:131 → 205

Ig; Immunoglobulin domain
XM_006495729.5 → XP_006495792.1 interleukin-18 receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006495792.1

UniProtKB/Swiss-Prot

Q61098

Conserved Domains (4) summary

PHA02785
Location:157 → 257

PHA02785; IL-beta-binding protein; Provisional

smart00410
Location:26 → 112

IG_like; Immunoglobulin like

pfam01582
Location:374 → 534

TIR; TIR domain

cl11960
Location:131 → 205

Ig; Immunoglobulin domain
XM_006495734.5 → XP_006495797.1 interleukin-18 receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006495797.1

UniProtKB/Swiss-Prot

Q61098

Conserved Domains (4) summary

PHA02785
Location:157 → 257

PHA02785; IL-beta-binding protein; Provisional

smart00410
Location:26 → 112

IG_like; Immunoglobulin like

pfam01582
Location:374 → 534

TIR; TIR domain

cl11960
Location:131 → 205

Ig; Immunoglobulin domain
XM_006495730.3 → XP_006495793.1 interleukin-18 receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006495793.1

UniProtKB/Swiss-Prot

Q61098

Conserved Domains (4) summary

PHA02785
Location:157 → 257

PHA02785; IL-beta-binding protein; Provisional

smart00410
Location:26 → 112

IG_like; Immunoglobulin like

pfam01582
Location:374 → 534

TIR; TIR domain

cl11960
Location:131 → 205

Ig; Immunoglobulin domain
XM_006495732.3 → XP_006495795.1 interleukin-18 receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006495795.1

UniProtKB/Swiss-Prot

Q61098

Conserved Domains (4) summary

PHA02785
Location:157 → 257

PHA02785; IL-beta-binding protein; Provisional

smart00410
Location:26 → 112

IG_like; Immunoglobulin like

pfam01582
Location:374 → 534

TIR; TIR domain

cl11960
Location:131 → 205

Ig; Immunoglobulin domain
XM_006495728.3 → XP_006495791.1 interleukin-18 receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006495791.1

UniProtKB/Swiss-Prot

Q61098

Conserved Domains (4) summary

PHA02785
Location:157 → 257

PHA02785; IL-beta-binding protein; Provisional

smart00410
Location:26 → 112

IG_like; Immunoglobulin like

pfam01582
Location:374 → 534

TIR; TIR domain

cl11960
Location:131 → 205

Ig; Immunoglobulin domain