Ikbkb inhibitor of kappaB kinase beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ikbkbprovided by MGI
Official Full Name: inhibitor of kappaB kinase betaprovided by MGI
Primary source: MGI:MGI:1338071
See related: Ensembl:ENSMUSG00000031537 AllianceGenome:MGI:1338071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IKK2; IKK-2; IKK-B; IKK[b]; IKKbeta; NFKBIKB; IKK-beta
Summary: Enables IkappaB kinase activity and protein phosphatase binding activity. Involved in canonical NF-kappaB signal transduction; cell surface receptor signaling pathway; and peptidyl-serine phosphorylation. Acts upstream of or within B cell homeostasis; positive regulation of cation channel activity; and positive regulation of sodium ion transport. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex and IkappaB kinase complex. Is expressed in several structures, including cerebral cortex; genitourinary system; heart; and musculature. Used to study immunodeficiency 15A. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 15.9), thymus adult (RPKM 12.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 11.42 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (23149228..23196605, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (22659205..22706589, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IkappaB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation.
Title: IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation.
Sustained activation of NF-kappaB through constitutively active IKKbeta leads to senescence bypass in murine dermal fibroblasts.
Title: Sustained activation of NF-κB through constitutively active IKKβ leads to senescence bypass in murine dermal fibroblasts.
IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model.
Title: IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model.
IKKbeta deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity.
Title: IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity.
Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice.
Title: Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice.
Endothelial-specific loss of IKKbeta disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth.
Title: Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth.
Macrophage DCLK1 promotes atherosclerosis via binding to IKKbeta and inducing inflammatory responses.
Title: Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses.
Phosphorylation by IKKbeta Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Title: Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Deficiency of IKKbeta in neurons ameliorates Alzheimer's disease pathology in APP- and tau-transgenic mice.
Title: Deficiency of IKKβ in neurons ameliorates Alzheimer's disease pathology in APP- and tau-transgenic mice.
IKKbeta increases neuropilin-2 and promotes the inhibitory function of CD9<sup>+</sup> Bregs to control allergic diseases.
Title: IKKβ increases neuropilin-2 and promotes the inhibitory function of CD9(+) Bregs to control allergic diseases.

Submit: New GeneRIF Correction See all GeneRIFs (231)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (7) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
contributes_to IkappaB kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IkappaB kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables IkappaB kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to IkappaB kinase activity	ISO Inferred from Sequence Orthology more info
enables IkappaB kinase activity	ISO Inferred from Sequence Orthology more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info	PubMed
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within I-kappaB phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cation channel activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of sodium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to cholecystokinin	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of CD40 receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of IkappaB kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of IkappaB kinase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of IkappaB kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit beta

Names: I-kappa-B kinase 2; I-kappa-B-kinase beta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta; serine/threonine protein kinase IKBKB

NP_001153246.1

EC 2.7.11.1

EC 2.7.11.10

NP_001411759.1

EC 2.7.11.1

EC 2.7.11.10

NP_001411760.1

EC 2.7.11.1

EC 2.7.11.10

NP_001411761.1

EC 2.7.11.1

EC 2.7.11.10

NP_034676.1

EC 2.7.11.1

EC 2.7.11.10

XP_006509085.1

EC 2.7.11.1

EC 2.7.11.10

XP_036009657.1

EC 2.7.11.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159774.2 → NP_001153246.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1

See identical proteins and their annotated locations for NP_001153246.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AC121835

Consensus CDS

CCDS52522.1

UniProtKB/Swiss-Prot

O88351, Q9R1J6

UniProtKB/TrEMBL

Q5D0E0

Related

ENSMUSP00000033939.7, ENSMUST00000033939.13

Conserved Domains (3) summary

smart00220
Location:15 → 290

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

pfam12179
Location:708 → 742

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
NM_001424830.1 → NP_001411759.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 3

Status: VALIDATED

Source sequence(s)

AC121835
NM_001424831.1 → NP_001411760.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 4

Status: VALIDATED

Source sequence(s)

AC121835
NM_001424832.1 → NP_001411761.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 5

Status: VALIDATED

Source sequence(s)

AC121835
NM_010546.3 → NP_034676.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2

See identical proteins and their annotated locations for NP_034676.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) retains sequence in the 3' coding region, which results in an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AC121835

Consensus CDS

CCDS22182.1

UniProtKB/Swiss-Prot

O88351, Q9R1J6

UniProtKB/TrEMBL

A0A0R4J0T4

Related

ENSMUSP00000064235.4, ENSMUST00000063401.10

Conserved Domains (2) summary

smart00220
Location:15 → 290

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

RNA

NR_188955.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC121835
NR_188956.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC121835
NR_188957.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC121835

Related

ENSMUST00000125314.8
NR_188958.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC121835
NR_188959.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC121835

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

23149228..23196605 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153764.1 → XP_036009657.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4

Conserved Domains (4) summary

cd17046
Location:31 → 111

Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins

pfam12179
Location:429 → 463

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam18397
Location:110 → 384

IKBKB_SDD; IQBAL scaffold dimerization domain

cl21453
Location:1 → 30

PKc_like; Protein Kinases, catalytic domain
XM_006509022.5 → XP_006509085.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3

Related

ENSMUSP00000138378.2, ENSMUST00000135326.8

Conserved Domains (3) summary

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

cd17046
Location:310 → 390

Ubl_IKKA_like; ubiquitin-like (Ubl) domain found in inhibitor of nuclear factor kappa-B kinases, IKK-alpha and IKK-beta, and similar proteins

pfam18397
Location:389 → 528

IKBKB_SDD; IQBAL scaffold dimerization domain