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    Ifi47 interferon gamma inducible protein 47 [ Mus musculus (house mouse) ]

    Gene ID: 15953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ifi47provided by MGI
    Official Full Name
    interferon gamma inducible protein 47provided by MGI
    Primary source
    MGI:MGI:99448
    See related
    Ensembl:ENSMUSG00000078920 AllianceGenome:MGI:99448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Igrd; Irgd; 47kDa; Iigp4; Iipg4; IRG-47; Ifggc1
    Summary
    Predicted to enable GTPase activity. Acts upstream of or within defense response. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in alimentary system; axial skeleton; and liver. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E18 (RPKM 10.2), large intestine adult (RPKM 9.9) and 18 other tissues See more
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    Genomic context

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    See Ifi47 in Genome Data Viewer
    Location:
    11 B1.2; 11 29.08 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48967414..48987814)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49076587..49096987)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene T cell specific GTPase 2 Neighboring gene predicted gene 12187 Neighboring gene STARR-positive B cell enhancer ABC_E8399 Neighboring gene Uncharacterized LOC133624656 Neighboring gene STARR-positive B cell enhancer ABC_E3946 Neighboring gene predicted gene 12188 Neighboring gene predicted gene, 51892 Neighboring gene olfactory receptor family 2 subfamily V member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The IRG-47 gene is IFN-gamma induced in B cells and encodes a protein with GTP-binding motifs. Gilly M, et al. J Immunol, 1992 May 15. PMID 1578148
    2. A promoter ISRE and dual 5' YY1 motifs control IFN-gamma induction of the IRG-47 G-protein gene. Gilly M, et al. Gene, 1996 Nov 14. PMID 8972906
    3. Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). Henry SC, et al. J Immunol, 2007 Nov 15. PMID 17982087
    4. p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. Butcher BA, et al. Infect Immun, 2005 Jun. PMID 15908352, Free PMC Article
    5. Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. Collazo CM, et al. J Exp Med, 2001 Jul 16. PMID 11457893, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon gamma inducible protein 47
    Names
    Immunity related GTPase family D
    interferon gamma inducible protein, 47 kDa
    interferon-gamma-inducible GTPase Ifggc1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271676.1 → NP_001258605.1  interferon gamma inducible protein 47

      See identical proteins and their annotated locations for NP_001258605.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL645688
      Consensus CDS
      CCDS24595.1
      UniProtKB/TrEMBL
      A0A1G5SK64, Q3U0K0, Q61635
      Conserved Domains (2) summary
      cd04104
      Location:75 → 270
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam05049
      Location:40 → 414
      IIGP; Interferon-inducible GTPase (IIGP)

    2. NM_001271677.1 → NP_001258606.1  interferon gamma inducible protein 47

      See identical proteins and their annotated locations for NP_001258606.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BU696734, CD742161, M63630
      Consensus CDS
      CCDS24595.1
      UniProtKB/TrEMBL
      A0A1G5SK64, Q3U0K0, Q61635
      Related
      ENSMUSP00000104825.2, ENSMUST00000109202.3
      Conserved Domains (2) summary
      cd04104
      Location:75 → 270
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam05049
      Location:40 → 414
      IIGP; Interferon-inducible GTPase (IIGP)

    3. NM_008330.2 → NP_032356.1  interferon gamma inducible protein 47

      See identical proteins and their annotated locations for NP_032356.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BY159742, CD742161, M63630
      Consensus CDS
      CCDS24595.1
      UniProtKB/TrEMBL
      A0A1G5SK64, Q3U0K0, Q61635
      Related
      ENSMUSP00000041975.7, ENSMUST00000046704.7
      Conserved Domains (2) summary
      cd04104
      Location:75 → 270
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam05049
      Location:40 → 414
      IIGP; Interferon-inducible GTPase (IIGP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      48967414..48987814
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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