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    PROM2 prominin 2 [ Homo sapiens (human) ]

    Gene ID: 150696, updated on 10-Dec-2024

    Summary

    Official Symbol
    PROM2provided by HGNC
    Official Full Name
    prominin 2provided by HGNC
    Primary source
    HGNC:HGNC:20685
    See related
    Ensembl:ENSG00000155066 MIM:617160; AllianceGenome:HGNC:20685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PROML2
    Summary
    This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
    Expression
    Biased expression in skin (RPKM 29.4), esophagus (RPKM 22.9) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PROM2 in Genome Data Viewer
    Location:
    2q11.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (95274449..95291302)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95780925..95797779)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95940197..95957050)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16184 Neighboring gene solute carrier family 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11741 Neighboring gene zinc finger protein 892 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:95905736-95906935 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:95930712-95930896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95964228-95964728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95971889-95972774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95974547-95975430 Neighboring gene potassium voltage-gated channel interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95981486-95981986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95984379-95984880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95992523-95993090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95996289-95996790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95996791-95997290 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:96008733-96008969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96040144-96040723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96041305-96041883 Neighboring gene fatty acid binding protein 7 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:96047731-96047930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96051115-96052015 Neighboring gene uncharacterized LOC124907858

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138714

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    colocalizes_with membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in microspike ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in prominosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in prominosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    prominin-2
    Names
    prominin-like protein 2
    prominin-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001165977.3NP_001159449.1  prominin-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001159449.1

      Status: REVIEWED

      Source sequence(s)
      AC009238, AF245304, HY060111
      Consensus CDS
      CCDS2012.1
      UniProtKB/Swiss-Prot
      A8K2V1, Q2HIX6, Q8N271, Q8NB84, Q8TAE2
      UniProtKB/TrEMBL
      B2R879
      Related
      ENSP00000385716.2, ENST00000403131.6
      Conserved Domains (2) summary
      pfam05478
      Location:25807
      Prominin; Prominin
      cl15454
      Location:531681
      HrpJ; HrpJ-like domain
    2. NM_001165978.3NP_001159450.1  prominin-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001159450.1

      Status: REVIEWED

      Source sequence(s)
      AC009238, AY358377, HY060111
      Consensus CDS
      CCDS2012.1
      UniProtKB/Swiss-Prot
      A8K2V1, Q2HIX6, Q8N271, Q8NB84, Q8TAE2
      UniProtKB/TrEMBL
      B2R879
      Related
      ENSP00000318270.9, ENST00000317620.14
      Conserved Domains (2) summary
      pfam05478
      Location:25807
      Prominin; Prominin
      cl15454
      Location:531681
      HrpJ; HrpJ-like domain
    3. NM_001321070.2NP_001307999.1  prominin-2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC009238, AI928825, BC025736, HY060111
      Conserved Domains (1) summary
      pfam05478
      Location:1461
      Prominin
    4. NM_144707.4NP_653308.2  prominin-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_653308.2

      Status: REVIEWED

      Source sequence(s)
      AF245303, AK290366, AK313267, BC025736, DB003233, HY060111
      Consensus CDS
      CCDS2012.1
      UniProtKB/Swiss-Prot
      A8K2V1, Q2HIX6, Q8N271, Q8NB84, Q8TAE2
      UniProtKB/TrEMBL
      B2R879
      Related
      ENSP00000318520.4, ENST00000317668.8
      Conserved Domains (2) summary
      pfam05478
      Location:25807
      Prominin; Prominin
      cl15454
      Location:531681
      HrpJ; HrpJ-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      95274449..95291302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443449.1XP_047299405.1  prominin-2 isoform X1

      UniProtKB/TrEMBL
      B2R879
    2. XM_011510672.3XP_011508974.1  prominin-2 isoform X2

      Conserved Domains (1) summary
      pfam05478
      Location:25476
      Prominin; Prominin
    3. XM_006712301.3XP_006712364.1  prominin-2 isoform X3

      See identical proteins and their annotated locations for XP_006712364.1

      Conserved Domains (1) summary
      pfam05478
      Location:1461
      Prominin

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791760.1 Reference GRCh38.p14 PATCHES

      Range
      36553..53406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332858.1XP_054188833.1  prominin-2 isoform X1

      UniProtKB/TrEMBL
      B2R879
    2. XM_054332859.1XP_054188834.1  prominin-2 isoform X2

    3. XM_054332860.1XP_054188835.1  prominin-2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      95780925..95797779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340662.1XP_054196637.1  prominin-2 isoform X1

      UniProtKB/TrEMBL
      B2R879
    2. XM_054340663.1XP_054196638.1  prominin-2 isoform X2

    3. XM_054340664.1XP_054196639.1  prominin-2 isoform X3