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    H2-Aa histocompatibility 2, class II antigen A, alpha [ Mus musculus (house mouse) ]

    Gene ID: 14960, updated on 27-Nov-2024

    Summary

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    Official Symbol
    H2-Aaprovided by MGI
    Official Full Name
    histocompatibility 2, class II antigen A, alphaprovided by MGI
    Primary source
    MGI:MGI:95895
    See related
    Ensembl:ENSMUSG00000036594 AllianceGenome:MGI:95895
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha
    Summary
    Enables peptide antigen binding activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II and positive regulation of T cell differentiation. Located in external side of plasma membrane and lysosome. Part of MHC class II protein complex. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); gastrointestinal system cancer (multiple); glomerulonephritis (multiple); hematologic cancer (multiple); and systemic scleroderma (multiple). Orthologous to human HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1) and HLA-DQA2 (major histocompatibility complex, class II, DQ alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 791.4), large intestine adult (RPKM 638.1) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See H2-Aa in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34501718..34506797, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34282744..34287823, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7524 Neighboring gene predicted gene 20506 Neighboring gene STARR-positive B cell enhancer ABC_E768 Neighboring gene STARR-positive B cell enhancer ABC_E1193 Neighboring gene STARR-positive B cell enhancer ABC_E8669 Neighboring gene histocompatibility 2, class II antigen A, beta 1 Neighboring gene STARR-positive B cell enhancer ABC_E1194 Neighboring gene STARR-positive B cell enhancer ABC_E2485 Neighboring gene STARR-positive B cell enhancer ABC_E397 Neighboring gene STARR-positive B cell enhancer ABC_E1505 Neighboring gene STARR-positive B cell enhancer ABC_E1940 Neighboring gene STARR-positive B cell enhancer ABC_E957 Neighboring gene STARR-seq mESC enhancer starr_42428 Neighboring gene histocompatibility 2, class II antigen E beta Neighboring gene STARR-positive B cell enhancer ABC_E8670 Neighboring gene STARR-positive B cell enhancer ABC_E8919 Neighboring gene histocompatibility 2, class II antigen E beta2 Neighboring gene STARR-seq mESC enhancer starr_42429

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells. Brocker T. J Exp Med, 1997 Oct 20. PMID 9334361, Free PMC Article
    2. Gastric mucosal hyperplasia via upregulation of gastrin induced by persistent activation of gastric innate immunity in major histocompatibility complex class II deficient mice. Fukui T, et al. Gut, 2006 May. PMID 16322110, Free PMC Article
    3. Functional adaptive CD4 Foxp3 T cells develop in MHC class II-deficient mice. Bochtler P, et al. J Immunol, 2006 Dec 15. PMID 17142726
    4. Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cell help during primary CD8+ T cell responses. Matthews KE, et al. J Immunol, 2007 Nov 1. PMID 17947646
    5. HLA-DQ6 transgenic mice resistance to experimental autoimmune myasthenia gravis is linked to reduced acetylcholine receptor-specific IFN-gamma, IL-2 and IL-10 production. Poussin MA, et al. J Autoimmun, 2001 Nov. PMID 11712854

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate an alternative mechanism where lymph node stromal cells (LNSCs) tolerize CD4(+) T cells through the presentation of self-antigens via transferred peptide-MHCII complexes of dendritic cell origin.
      Title: Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance.
    2. Data show that MHC class II(+)Fas(+) BM cells were closely associated with CD4(+) T cells in the BM of affected animals.
      Title: MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.
    3. Analysis of CD8(+) T-cell-specific responses in A2xneu mice indicated that the priming activity of old A2xneu mice to induce an immune response was diminished compared with young animals.
      Title: Implications of aging and self-tolerance on the generation of immune and antitumor immune responses.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide antigen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within antigen processing and presentation of peptide antigen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide antigen assembly with MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MHC class II protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MHC class II protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histocompatibility 2, class II antigen A, alpha
    Names
    H-2 class II histocompatibility antigen, A-B alpha chain
    H-2 class II histocompatibility antigen, A-F alpha chain
    H-2 class II histocompatibility antigen, A-K alpha chain
    H-2 class II histocompatibility antigen, A-Q alpha chain
    H-2 class II histocompatibility antigen, A-R alpha chain
    H-2 class II histocompatibility antigen, A-S alpha chain
    H-2 class II histocompatibility antigen, A-U alpha chain
    MHC class II antigen alpha chain
    MHC-II I-A(d) alpha
    histocompatibility 2, class II antigen A, alpha, promoter 1
    major histocompatibility protein class II alpha chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010378.3 → NP_034508.2  histocompatibility 2, class II antigen A, alpha precursor

      See identical proteins and their annotated locations for NP_034508.2

      Status: VALIDATED

      Source sequence(s)
      AK002532, BY604245, CR974422
      Consensus CDS
      CCDS28645.1
      UniProtKB/Swiss-Prot
      O78195, P01910, P14434
      Related
      ENSMUSP00000046105.7, ENSMUST00000040655.14
      Conserved Domains (3) summary
      cd05767
      Location:113 → 206
      IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00993
      Location:31 → 109
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      pfam16196
      Location:204 → 255
      C1-set_C; C1-set C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34501718..34506797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01910.2 GenPept UniProtKB/Swiss-Prot:P01910
    P04227.1 GenPept UniProtKB/Swiss-Prot:P04227
    P04228.1 GenPept UniProtKB/Swiss-Prot:P04228
    P14434.2 GenPept UniProtKB/Swiss-Prot:P14434
    P14435.1 GenPept UniProtKB/Swiss-Prot:P14435
    P14436.1 GenPept UniProtKB/Swiss-Prot:P14436
    P14437.1 GenPept UniProtKB/Swiss-Prot:P14437
    P14438.1 GenPept UniProtKB/Swiss-Prot:P14438
    P23150.1 GenPept UniProtKB/Swiss-Prot:P23150

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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