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    Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B [ Mus musculus (house mouse) ]

    Gene ID: 14727, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lilrb4bprovided by MGI
    Official Full Name
    leukocyte immunoglobulin-like receptor, subfamily B, member 4Bprovided by MGI
    Primary source
    MGI:MGI:102702
    See related
    Ensembl:ENSMUSG00000112023 AllianceGenome:MGI:102702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gp49; Gp49a; Lilr4b
    Summary
    Predicted to enable several functions, including apolipoprotein binding activity; fibronectin binding activity; and transmembrane receptor protein tyrosine kinase inhibitor activity. Involved in mast cell activation. Located in cell surface. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 4.8), mammary gland adult (RPKM 4.7) and 21 other tissues See more
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    Genomic context

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    See Lilrb4b in Genome Data Viewer
    Location:
    10 B3; 10 25.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (51356757..51362417)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (51480612..51486329)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26656 Neighboring gene STARR-seq mESC enhancer starr_26657 Neighboring gene predicted gene, 53627 Neighboring gene STARR-seq mESC enhancer starr_26658 Neighboring gene leukocyte immunoglobulin-like receptor subfamily A member 6 Neighboring gene STARR-seq mESC enhancer starr_26659 Neighboring gene predicted gene, 40645 Neighboring gene leukocyte immunoglobulin-like receptor, subfamily B, member 4A Neighboring gene predicted gene, 46224

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily. Arm JP, et al. J Biol Chem, 1991 Aug 25. PMID 1714901
    2. Stimulatory function of gp49A, a murine Ig-like receptor, in rat basophilic leukemia cells. Lee KH, et al. J Immunol, 2000 Nov 1. PMID 11046024
    3. Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. Castells MC, et al. J Biol Chem, 1994 Mar 18. PMID 8132564
    4. The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin superfamily. McCormick MJ, et al. Immunogenetics, 1999 Dec. PMID 10630292
    5. Natural killer cells and mast cells from gp49B null mutant mice are functional. Rojo S, et al. Mol Cell Biol, 2000 Oct. PMID 10982834, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.
      Title: LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Fc receptor mediated inhibitory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mast cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of IP-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytotoxic T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-5 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of monocyte activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell anergy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tolerance induction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte immunoglobulin-like receptor subfamily B member 4B
    Names
    glycoprotein 49 A
    mast cell surface glycoprotein Gp49A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291892.2 → NP_001278821.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153530
      Conserved Domains (1) summary
      cl11960
      Location:37 → 131
      Ig; Immunoglobulin domain

    2. NM_001291893.2 → NP_001278822.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 3 precursor

      See identical proteins and their annotated locations for NP_001278822.1

      Status: VALIDATED

      Source sequence(s)
      AC153530
      Consensus CDS
      CCDS88004.1
      UniProtKB/TrEMBL
      A0A1W2P6F1, A0A1W2P7F3
      Related
      ENSMUSP00000151625.2, ENSMUST00000219661.2
      Conserved Domains (1) summary
      cl11960
      Location:29 → 123
      Ig; Immunoglobulin domain

    3. NM_001419401.1 → NP_001406330.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153530

    4. NM_008147.3 → NP_032173.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 1 precursor

      See identical proteins and their annotated locations for NP_032173.1

      Status: VALIDATED

      Source sequence(s)
      AC153530
      Consensus CDS
      CCDS23831.1
      UniProtKB/Swiss-Prot
      Q549E3, Q61450
      UniProtKB/TrEMBL
      A0A1W2P7X1
      Related
      ENSMUSP00000099958.4, ENSMUST00000102894.6
      Conserved Domains (1) summary
      cl11960
      Location:124 → 218
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      51356757..51362417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61450.1 GenPept UniProtKB/Swiss-Prot:Q61450

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Molecular Biology Databases
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