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    Gng2 guanine nucleotide binding protein (G protein), gamma 2 [ Mus musculus (house mouse) ]

    Gene ID: 14702, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gng2provided by MGI
    Official Full Name
    guanine nucleotide binding protein (G protein), gamma 2provided by MGI
    Primary source
    MGI:MGI:102705
    See related
    Ensembl:ENSMUSG00000043004 AllianceGenome:MGI:102705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hg3f1
    Summary
    Predicted to enable G-protein beta-subunit binding activity and GTPase activity. Acts upstream of or within G protein-coupled receptor signaling pathway and fibroblast proliferation. Is active in synapse. Is expressed in early conceptus; genitourinary system; intestine; nervous system; and neural retina. Orthologous to human GNG2 (G protein subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 89.6), whole brain E14.5 (RPKM 69.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gng2 in Genome Data Viewer
    Location:
    14 A3; 14 11.17 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (19922626..20027893, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (19872558..19977825, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nidogen 2 Neighboring gene STARR-positive B cell enhancer ABC_E9891 Neighboring gene DNA segment, Chr 14, ERATO Doi 670, expressed Neighboring gene RNA transcription, translation and transport factor Neighboring gene STARR-seq mESC enhancer starr_36086 Neighboring gene STARR-seq mESC enhancer starr_36089 Neighboring gene VISTA enhancer mm1498 Neighboring gene STARR-seq mESC enhancer starr_36096 Neighboring gene STARR-seq mESC enhancer starr_36097 Neighboring gene STARR-seq mESC enhancer starr_36099 Neighboring gene SAYSVFN motif domain containing 1 Neighboring gene predicted gene, 41104

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A G protein gamma subunit shares homology with ras proteins. Gautam N, et al. Science, 1989 May 26. PMID 2499046
    2. Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit. Modarressi MH, et al. Biochem Biophys Res Commun, 2000 Jun 7. PMID 10833460
    3. The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2. Luo VM, et al. Mol Cell Biol, 2024 Jan. PMID 38270191,
    4. In vivo expression of G-protein beta1gamma2 dimer in adult mouse skeletal muscle alters L-type calcium current and excitation-contraction coupling. Weiss N, et al. J Physiol, 2010 Aug 1. PMID 20547679, Free PMC Article
    5. Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. Hurley JB, et al. Proc Natl Acad Sci U S A, 1984 Nov. PMID 6438626, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the gamma-Subunit Gng2.
      Title: The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.
    2. miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
      Title: miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
    3. It was concluded that GIRK2, through its dual responsiveness to G protein beta-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity.
      Title: Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels.
    4. signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018.
      Title: Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 1110003P13Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G-protein beta-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Names
    g gamma-I
    heterotrimeric guanine nucleotide-binding protein 3f1
    NP_001033726.1
    NP_001272837.1
    NP_001272838.1
    NP_001272839.1
    NP_001272840.1
    NP_001411396.1
    NP_001411397.1
    NP_034445.1
    XP_030103512.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038637.1 → NP_001033726.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_001033726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AC130831, AK158697, AK160396, BY245532
      Consensus CDS
      CCDS26840.1
      UniProtKB/Swiss-Prot
      P63213, Q3TYE8
      Related
      ENSMUSP00000125000.2, ENSMUST00000159073.8
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    2. NM_001285908.1 → NP_001272837.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_001272837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AC130831, BY245532, W48309
      Consensus CDS
      CCDS26840.1
      UniProtKB/Swiss-Prot
      P63213, Q3TYE8
      Related
      ENSMUSP00000124153.2, ENSMUST00000162425.8
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    3. NM_001285909.1 → NP_001272838.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_001272838.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AC130831, BY245532, CA324196
      Consensus CDS
      CCDS26840.1
      UniProtKB/Swiss-Prot
      P63213, Q3TYE8
      Related
      ENSMUSP00000055256.8, ENSMUST00000055100.14
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    4. NM_001285910.1 → NP_001272839.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_001272839.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AC130831, AK158697, BY108799
      Consensus CDS
      CCDS26840.1
      UniProtKB/Swiss-Prot
      P63213, Q3TYE8
      Related
      ENSMUSP00000125141.2, ENSMUST00000159028.8
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    5. NM_001285911.1 → NP_001272840.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_001272840.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-6 encode the same protein.
      Source sequence(s)
      AC130831, W48309
      Consensus CDS
      CCDS26840.1
      UniProtKB/Swiss-Prot
      P63213, Q3TYE8
      Related
      ENSMUSP00000124725.2, ENSMUST00000161247.2
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    6. NM_001424467.1 → NP_001411396.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      Status: VALIDATED

      Source sequence(s)
      AC130831
      UniProtKB/Swiss-Prot
      P63213, Q3TYE8

    7. NM_001424468.1 → NP_001411397.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      Status: VALIDATED

      Source sequence(s)
      AC130831
      UniProtKB/Swiss-Prot
      P63213, Q3TYE8

    8. NM_010315.4 → NP_034445.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_034445.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 encode the same protein.
      Source sequence(s)
      AC130831, AK158697, AK160396, BY245532
      Consensus CDS
      CCDS26840.1
      UniProtKB/Swiss-Prot
      P63213, Q3TYE8
      Related
      ENSMUSP00000125697.2, ENSMUST00000160013.8
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      19922626..20027893 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247652.1 → XP_030103512.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

      UniProtKB/Swiss-Prot
      P63213, Q3TYE8
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63213.2 GenPept UniProtKB/Swiss-Prot:P63213

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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