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    PTGR2 prostaglandin reductase 2 [ Homo sapiens (human) ]

    Gene ID: 145482, updated on 10-Dec-2024

    Summary

    Official Symbol
    PTGR2provided by HGNC
    Official Full Name
    prostaglandin reductase 2provided by HGNC
    Primary source
    HGNC:HGNC:20149
    See related
    Ensembl:ENSG00000140043 MIM:608642; AllianceGenome:HGNC:20149
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR2; ZADH1; HEL-S-298
    Summary
    This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
    Expression
    Ubiquitous expression in heart (RPKM 10.6), thyroid (RPKM 9.3) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTGR2 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73851831..73885726)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68059477..68093373)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74318534..74352429)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene MIDEAS antisense RNA 1 Neighboring gene small nucleolar RNA U13 Neighboring gene long intergenic non-protein coding RNA 2274 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74302771-74302949 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74305149-74305318 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74318268-74318670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8721 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8722 Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74416687-74417687 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74418757-74419055 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Neighboring gene coenzyme Q6, monooxygenase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ZNF410

    Clone Names

    • FLJ39091, FLJ99229, DKFZp686P10120

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in prostaglandin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    prostaglandin reductase 2
    Names
    15-oxoprostaglandin 13-reductase
    15-oxoprostaglandin-delta13-reductase
    PRG-2
    epididymis secretory protein Li 298
    epididymis secretory sperm binding protein
    zinc binding alcohol dehydrogenase, domain containing 1
    zinc-binding alcohol dehydrogenase domain-containing protein 1
    NP_001139626.1
    NP_001139627.1
    NP_001358254.1
    NP_001358255.1
    NP_001358256.1
    NP_001358257.1
    NP_001358258.1
    NP_001358259.1
    NP_001358260.1
    NP_001358261.1
    NP_001358263.1
    NP_001358264.1
    NP_689657.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146154.2NP_001139626.1  prostaglandin reductase 2 isoform 1

      See identical proteins and their annotated locations for NP_001139626.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC005520, AY346133, BP357520, BU616297
      Consensus CDS
      CCDS9820.1
      UniProtKB/Swiss-Prot
      Q3L8A4, Q6MZH8, Q8N8N7
      UniProtKB/TrEMBL
      V9HW32
      Related
      ENSP00000452280.1, ENST00000555661.6
      Conserved Domains (1) summary
      cd08293
      Location:1345
      PTGR2; Prostaglandin reductase
    2. NM_001146155.3NP_001139627.1  prostaglandin reductase 2 isoform 1

      See identical proteins and their annotated locations for NP_001139627.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC005520, BC059364, BU616297, DR158023
      Consensus CDS
      CCDS9820.1
      UniProtKB/Swiss-Prot
      Q3L8A4, Q6MZH8, Q8N8N7
      UniProtKB/TrEMBL
      V9HW32
      Related
      ENSP00000450975.1, ENST00000555228.5
      Conserved Domains (1) summary
      cd08293
      Location:1345
      PTGR2; Prostaglandin reductase
    3. NM_001371325.1NP_001358254.1  prostaglandin reductase 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC005520
      Consensus CDS
      CCDS9820.1
      UniProtKB/Swiss-Prot
      Q3L8A4, Q6MZH8, Q8N8N7
      UniProtKB/TrEMBL
      V9HW32
      Conserved Domains (1) summary
      cd08293
      Location:1345
      PTGR2; Prostaglandin reductase
    4. NM_001371326.1NP_001358255.1  prostaglandin reductase 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC005520
      Conserved Domains (1) summary
      cl16912
      Location:1288
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    5. NM_001371327.1NP_001358256.1  prostaglandin reductase 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC005520
      UniProtKB/TrEMBL
      G3V3Y1
      Conserved Domains (1) summary
      cl16912
      Location:1275
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    6. NM_001371328.1NP_001358257.1  prostaglandin reductase 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC005520
      UniProtKB/TrEMBL
      G3V3Y1
      Conserved Domains (1) summary
      cl16912
      Location:1275
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    7. NM_001371329.1NP_001358258.1  prostaglandin reductase 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC005520
      UniProtKB/TrEMBL
      G3V3Y1
      Conserved Domains (1) summary
      cl16912
      Location:1275
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    8. NM_001371330.1NP_001358259.1  prostaglandin reductase 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC005520
      Consensus CDS
      CCDS91902.1
      UniProtKB/TrEMBL
      G3V2R9
      Conserved Domains (1) summary
      cl16912
      Location:1211
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    9. NM_001371331.1NP_001358260.1  prostaglandin reductase 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC005520
      Consensus CDS
      CCDS91902.1
      UniProtKB/TrEMBL
      G3V2R9
      Conserved Domains (1) summary
      cl16912
      Location:1211
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    10. NM_001371332.1NP_001358261.1  prostaglandin reductase 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC005520
      Consensus CDS
      CCDS91902.1
      UniProtKB/TrEMBL
      G3V2R9
      Related
      ENSP00000450824.1, ENST00000553813.1
      Conserved Domains (1) summary
      cl16912
      Location:1211
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    11. NM_001371334.1NP_001358263.1  prostaglandin reductase 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC005520
      Conserved Domains (1) summary
      cl16912
      Location:1117
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    12. NM_001371335.1NP_001358264.1  prostaglandin reductase 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC005520
      Conserved Domains (1) summary
      cl16912
      Location:152
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    13. NM_152444.4NP_689657.1  prostaglandin reductase 2 isoform 1

      See identical proteins and their annotated locations for NP_689657.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC005520, BC059364, BU616297
      Consensus CDS
      CCDS9820.1
      UniProtKB/Swiss-Prot
      Q3L8A4, Q6MZH8, Q8N8N7
      UniProtKB/TrEMBL
      V9HW32
      Related
      ENSP00000267568.4, ENST00000267568.8
      Conserved Domains (1) summary
      cd08293
      Location:1345
      PTGR2; Prostaglandin reductase

    RNA

    1. NR_163921.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005520

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      73851831..73885726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      68059477..68093373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)