U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PPP1R36 protein phosphatase 1 regulatory subunit 36 [ Homo sapiens (human) ]

    Gene ID: 145376, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PPP1R36provided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory subunit 36provided by HGNC
    Primary source
    HGNC:HGNC:20097
    See related
    Ensembl:ENSG00000165807 MIM:619923; AllianceGenome:HGNC:20097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf50
    Summary
    Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 17.6), stomach (RPKM 2.2) and 4 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PPP1R36 in Genome Data Viewer
    Location:
    14q23.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64549961..64589381)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (58757758..58797178)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65016679..65056099)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8535 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64970928-64971598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5837 Neighboring gene HSPA2 and ZBTB1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8536 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5839 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65039864-65040400 Neighboring gene heat shock protein family A (Hsp70) member 2 Neighboring gene nucleoporin 50 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65099836-65100338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65142104-65142604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65142605-65143105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65146682-65147226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65169421-65169922 Neighboring gene NANOG hESC enhancer GRCh37_chr14:65175156-65175657 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65181995-65182914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65182915-65183832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65184752-65185669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:65194651-65195302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65195956-65196607 Neighboring gene pleckstrin homology and RhoGEF domain containing G3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65202813-65203735 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:65203736-65204657 Neighboring gene spectrin beta, erythrocytic

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    2. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. Xiao T, et al. Proc Natl Acad Sci U S A, 2018 Jul 31. PMID 29987050, Free PMC Article
    3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein phosphatase 1 regulatory subunit 36

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172365.3 → NP_758953.1  protein phosphatase 1 regulatory subunit 36

      See identical proteins and their annotated locations for NP_758953.1

      Status: VALIDATED

      Source sequence(s)
      AL049869, BC068989
      Consensus CDS
      CCDS9767.1
      UniProtKB/Swiss-Prot
      Q6NTH6, Q96LQ0
      Related
      ENSP00000298705.1, ENST00000298705.6
      Conserved Domains (1) summary
      pfam14895
      Location:79 → 412
      PPPI_inhib; Protein phosphatase 1 inhibitor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      64549961..64589381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430998.1 → XP_047286954.1  protein phosphatase 1 regulatory subunit 36 isoform X4

    2. XM_011536468.4 → XP_011534770.1  protein phosphatase 1 regulatory subunit 36 isoform X3

      Conserved Domains (1) summary
      pfam14895
      Location:79 → 367
      PPPI_inhib; Protein phosphatase 1 inhibitor

    3. XM_047430999.1 → XP_047286955.1  protein phosphatase 1 regulatory subunit 36 isoform X4

    4. XM_005267355.5 → XP_005267412.1  protein phosphatase 1 regulatory subunit 36 isoform X2

      Conserved Domains (1) summary
      pfam14895
      Location:35 → 368
      PPPI_inhib; Protein phosphatase 1 inhibitor

    5. XM_047431000.1 → XP_047286956.1  protein phosphatase 1 regulatory subunit 36 isoform X4

    6. XM_005267354.5 → XP_005267411.1  protein phosphatase 1 regulatory subunit 36 isoform X1

      Conserved Domains (1) summary
      pfam14895
      Location:67 → 400
      PPPI_inhib; Protein phosphatase 1 inhibitor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      58757758..58797178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375437.1 → XP_054231412.1  protein phosphatase 1 regulatory subunit 36 isoform X4

    2. XM_054375436.1 → XP_054231411.1  protein phosphatase 1 regulatory subunit 36 isoform X3

    3. XM_054375438.1 → XP_054231413.1  protein phosphatase 1 regulatory subunit 36 isoform X4

    4. XM_054375435.1 → XP_054231410.1  protein phosphatase 1 regulatory subunit 36 isoform X2

    5. XM_054375439.1 → XP_054231414.1  protein phosphatase 1 regulatory subunit 36 isoform X4

    6. XM_054375434.1 → XP_054231409.1  protein phosphatase 1 regulatory subunit 36 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LQ0.1 GenPept UniProtKB/Swiss-Prot:Q96LQ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools