Dpagt1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpagt1provided by MGI
Official Full Name: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1provided by MGI
Primary source: MGI:MGI:1196396
See related: Ensembl:ENSMUSG00000032123 AllianceGenome:MGI:1196396
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GPT; G1PT; Gnpta; Dpagt2
Summary: Enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process; dolichol metabolic process; and dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ij and congenital myasthenic syndrome 13. Orthologous to human DPAGT1 (dolichyl-phosphate N-acetylglucosaminephosphotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 30.3), ovary adult (RPKM 28.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44237314..44247374)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44325857..44333895)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136449 (e-PCR)
- UniSTS:210435

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

BB138393 (e-PCR)
- UniSTS:208367

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	ISO Inferred from Sequence Orthology more info
enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-N-acetylglucosamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in dolichol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dolichol-linked oligosaccharide biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Names: N-acetylglucosamine-1-phosphate transferase; UDP-N-acetylglucosamine lysosomal enzyme N-acetylglucosamine phosphotransferase; dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); dolichyl-phosphate alpha-N-acetylglucosaminephosphotransferase 2

NP_001351393.1

EC 2.7.8.15

NP_031901.2

EC 2.7.8.15

XP_006510054.1

EC 2.7.8.15

XP_006510055.1

EC 2.7.8.15

XP_006510058.1

EC 2.7.8.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364464.1 → NP_001351393.1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 2

Status: VALIDATED

Source sequence(s)

AK008246, BM211613, BM899494, CN665943

UniProtKB/TrEMBL

Q9CPT1

Conserved Domains (1) summary

cd06855
Location:1 → 210

GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
NM_007875.3 → NP_031901.2 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform 1

See identical proteins and their annotated locations for NP_031901.2

Status: VALIDATED

Source sequence(s)

AC122428, AC124577

Consensus CDS

CCDS23104.1

UniProtKB/Swiss-Prot

P42867, Q921W5

Related

ENSMUSP00000056282.4, ENSMUST00000054708.5

Conserved Domains (1) summary

cd06855
Location:31 → 319

GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

44237314..44247374

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509991.2 → XP_006510054.1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X1

Conserved Domains (1) summary

cd06855
Location:3 → 286

GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
XM_006509992.3 → XP_006510055.1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X2

Conserved Domains (1) summary

cd06855
Location:35 → 264

GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
XM_006509995.3 → XP_006510058.1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X3

See identical proteins and their annotated locations for XP_006510058.1

UniProtKB/TrEMBL

Q9CPT1

Conserved Domains (1) summary

cd06855
Location:1 → 210

GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...