Dnase1 deoxyribonuclease I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnase1provided by MGI
Official Full Name: deoxyribonuclease Iprovided by MGI
Primary source: MGI:MGI:103157
See related: Ensembl:ENSMUSG00000005980 AllianceGenome:MGI:103157
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dnl1; DNaseI
Summary: Enables deoxyribonuclease I activity. Involved in several processes, including DNA catabolic process; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in extracellular region; nuclear envelope; and zymogen granule. Predicted to be active in nucleus. Is expressed in jejunum; metanephros; and tongue. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human DNASE1 (deoxyribonuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 666.1), duodenum adult (RPKM 123.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.37 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (3855007..3857888)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4036958..4040024)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models.
Title: A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models.
The protective effect of DNase I in retinal vein occlusion.
Title: The protective effect of DNase I in retinal vein occlusion.
Targeting NETs using dual-active DNase1 variants.
Title: Targeting NETs using dual-active DNase1 variants.
Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.
Title: Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus.
Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris.
Title: Comparison of the secretory murine DNase1 family members expressed in Pichia pastoris.
this model recapitulates the female bias seen in human SLE patients since female Dnase1-deficient mice produced the highest concentrations of autoantibodies and had more severe kidney damage than males.
Title: Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease.
DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps.
Title: Host DNases prevent vascular occlusion by neutrophil extracellular traps.
HMGN1 binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors.
Title: HMGN1 modulates nucleosome occupancy and DNase I hypersensitivity at the CpG island promoters of embryonic stem cells.
Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 and a consequent down-regulation of renal DNaseI by transcriptional interference.
Title: Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis.
silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll like receptors and Clec4e, leading to progression of both murine and human lupus nephritis
Title: Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of Toll like receptors and the Clec4e.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Dnase1 (e-PCR), detects polymorphism
- UniSTS:142857

NoName (e-PCR)
- UniSTS:488242

AI788650 (e-PCR)
- UniSTS:165970

U00478 (e-PCR)
- UniSTS:125635

Dnase1 (e-PCR), detects polymorphism
- UniSTS:506856

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables deoxyribonuclease I activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyribonuclease I activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables deoxyribonuclease I activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neutrophil activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of acute inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neutrophil mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in zymogen granule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: deoxyribonuclease-1

NP_001344072.1

EC 3.1.21.1

NP_001403712.1

EC 3.1.21.1

NP_001403713.1

EC 3.1.21.1

NP_034191.3

EC 3.1.21.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357143.2 → NP_001344072.1 deoxyribonuclease-1 precursor

Status: VALIDATED

Source sequence(s)

AC087900

Consensus CDS

CCDS27913.1

UniProtKB/Swiss-Prot

O70532, P49183

UniProtKB/TrEMBL

Q14BW6, Q14BW7, Q91WL7

Related

ENSMUSP00000113119.2, ENSMUST00000120009.8

Conserved Domains (1) summary

smart00476
Location:20 → 282

DNaseIc; deoxyribonuclease I
NM_001416783.1 → NP_001403712.1 deoxyribonuclease-1 precursor

Status: VALIDATED

Source sequence(s)

AC087900

UniProtKB/Swiss-Prot

O70532, P49183

UniProtKB/TrEMBL

Q14BW6, Q14BW7, Q91WL7
NM_001416784.1 → NP_001403713.1 deoxyribonuclease-1 precursor

Status: VALIDATED

Source sequence(s)

AC087900

UniProtKB/Swiss-Prot

O70532, P49183

UniProtKB/TrEMBL

Q14BW6, Q14BW7, Q91WL7

Related

ENSMUST00000125961.8
NM_010061.6 → NP_034191.3 deoxyribonuclease-1 precursor

See identical proteins and their annotated locations for NP_034191.3

Status: VALIDATED

Source sequence(s)

AC087900

Consensus CDS

CCDS27913.1

UniProtKB/Swiss-Prot

O70532, P49183

UniProtKB/TrEMBL

Q14BW6, Q14BW7, Q91WL7

Related

ENSMUSP00000006136.5, ENSMUST00000006136.11

Conserved Domains (1) summary

smart00476
Location:20 → 282

DNaseIc; deoxyribonuclease I