Cyb561 cytochrome b-561 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyb561provided by MGI
Official Full Name: cytochrome b-561provided by MGI
Primary source: MGI:MGI:103253
See related: Ensembl:ENSMUSG00000019590 AllianceGenome:MGI:103253
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables transmembrane monodehydroascorbate reductase activity. Involved in ascorbate homeostasis and intracellular iron ion homeostasis. Located in chromaffin granule membrane. Is expressed in several structures, including genitourinary system; gut; nervous system; node; and nose. Orthologous to human CYB561 (cytochrome b561). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in genital fat pad adult (RPKM 144.4), adrenal adult (RPKM 27.6) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 68.81 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (105824528..105844157, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (105933702..105945019, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

dihydrolipoic acid (DHLA)-dependent reduction of these two Cyt-b561 proteins
Title: Dihydrolipoic acid reduces cytochrome b561 proteins.
expression of Cytochrome b561, is androgen regulated in the context of CaP cells and its increased expression in castration recurrent prostate cancer reflects increased androgen receptor signaling in tumor cells
Title: Elevated expression of the cytochrome b561, a neuroendocrine vesicle protein, in castration resistant prostate tumors.
Data show that four members of the b561 family of predicted ferric reductases: mouse cytochrome b561, human duodenal cytochrome b, and mouse stromal cell-derived receptor 2, have ferric reductase activity.
Title: Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane monodehydroascorbate reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane monodehydroascorbate reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ascorbate homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in ascorbate homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular iron ion homeostasis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromaffin granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in chromaffin granule membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transmembrane ascorbate-dependent reductase CYB561

Names: CGCytb; chromaffin granule Cyt b561; cytochrome b561

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356374.2 → NP_001343303.1 transmembrane ascorbate-dependent reductase CYB561 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL596246

Consensus CDS

CCDS25542.1

UniProtKB/Swiss-Prot

Q3TEC6, Q60720, Q9D6C9

UniProtKB/TrEMBL

Q8CE89

Conserved Domains (1) summary

cl23723
Location:43 → 184

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
NM_001430914.1 → NP_001417843.1 transmembrane ascorbate-dependent reductase CYB561 isoform 2

Status: VALIDATED

Source sequence(s)

AL596246

UniProtKB/TrEMBL

V9GX11
NM_001430915.1 → NP_001417844.1 transmembrane ascorbate-dependent reductase CYB561 isoform 2

Status: VALIDATED

Source sequence(s)

AL596246

UniProtKB/TrEMBL

V9GX11
NM_007805.6 → NP_031831.2 transmembrane ascorbate-dependent reductase CYB561 isoform 1

See identical proteins and their annotated locations for NP_031831.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL596246

Consensus CDS

CCDS25542.1

UniProtKB/Swiss-Prot

Q3TEC6, Q60720, Q9D6C9

UniProtKB/TrEMBL

Q8CE89

Related

ENSMUSP00000019734.5, ENSMUST00000019734.11

Conserved Domains (1) summary

cl23723
Location:43 → 184

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

105824528..105844157 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156276.1 → XP_036012169.1 transmembrane ascorbate-dependent reductase CYB561 isoform X1

Conserved Domains (1) summary

cd08763
Location:81 → 222

Cyt_b561_CYB561; Vertebrate cytochrome b(561), CYB561 gene product
XM_036156277.1 → XP_036012170.1 transmembrane ascorbate-dependent reductase CYB561 isoform X2

UniProtKB/TrEMBL

Q8CE89

Conserved Domains (1) summary

cl23723
Location:53 → 194

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_006532131.4 → XP_006532194.1 transmembrane ascorbate-dependent reductase CYB561 isoform X3

See identical proteins and their annotated locations for XP_006532194.1

UniProtKB/Swiss-Prot

Q3TEC6, Q60720, Q9D6C9

UniProtKB/TrEMBL

Q8CE89

Conserved Domains (1) summary

cl23723
Location:43 → 184

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_006532132.5 → XP_006532195.1 transmembrane ascorbate-dependent reductase CYB561 isoform X3

See identical proteins and their annotated locations for XP_006532195.1

UniProtKB/Swiss-Prot

Q3TEC6, Q60720, Q9D6C9

UniProtKB/TrEMBL

Q8CE89

Conserved Domains (1) summary

cl23723
Location:43 → 184

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_036156278.1 → XP_036012171.1 transmembrane ascorbate-dependent reductase CYB561 isoform X4

Conserved Domains (1) summary

cl23723
Location:43 → 174

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_036156279.1 → XP_036012172.1 transmembrane ascorbate-dependent reductase CYB561 isoform X4

Conserved Domains (1) summary

cl23723
Location:43 → 174

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...
XM_006532134.5 → XP_006532197.1 transmembrane ascorbate-dependent reductase CYB561 isoform X4

Related

ENSMUSP00000138931.2, ENSMUST00000184086.8

Conserved Domains (1) summary

cl23723
Location:43 → 174

Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...