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    LOC127897470 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:40712785-40713352 [ Homo sapiens (human) ]

    Gene ID: 127897470, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC127897470
    Gene description
    OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:40712785-40713352
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Dec 2022]
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    Genomic context

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    See LOC127897470 in Genome Data Viewer
    Location:
    chromosome: X
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (40853532..40854099)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (40254739..40255306)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (40712785..40713352)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:40693428-40693928 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:40693929-40694429 Neighboring gene TNIP2 pseudogene 1 Neighboring gene makorin ring finger protein 4, pseudogene Neighboring gene hESC enhancers GRCh37_chrX:40703903-40704854 and GRCh37_chrX:40704855-40705806 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:40710515-40711082 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:40712217-40712784 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:40726337-40726836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29552 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:40737647-40738520 Neighboring gene syndecan binding protein pseudogene 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:40767632-40768831 Neighboring gene ribosomal protein L32 pseudogene 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_146837.1 

      Range
      101..668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      40853532..40854099
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      40254739..40255306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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